Working Memory Load Modulates Neuronal Coupling
© 2018 Published by Oxford University Press. There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press (OUP)
2021
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| Online Access: | https://hdl.handle.net/1721.1/135795 |
| _version_ | 1811076387536109568 |
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| author | Pinotsis, Dimitris A Buschman, Timothy J Miller, Earl K |
| author_facet | Pinotsis, Dimitris A Buschman, Timothy J Miller, Earl K |
| author_sort | Pinotsis, Dimitris A |
| collection | MIT |
| description | © 2018 Published by Oxford University Press. There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1-3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC-FEF-LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load. |
| first_indexed | 2024-09-23T10:20:39Z |
| format | Article |
| id | mit-1721.1/135795 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:20:39Z |
| publishDate | 2021 |
| publisher | Oxford University Press (OUP) |
| record_format | dspace |
| spelling | mit-1721.1/1357952021-10-28T04:31:36Z Working Memory Load Modulates Neuronal Coupling Pinotsis, Dimitris A Buschman, Timothy J Miller, Earl K © 2018 Published by Oxford University Press. There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1-3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC-FEF-LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load. 2021-10-27T20:29:20Z 2021-10-27T20:29:20Z 2019 2019-10-03T16:18:43Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135795 en 10.1093/CERCOR/BHY065 Cerebral Cortex Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Oxford University Press (OUP) Oxford University Press |
| spellingShingle | Pinotsis, Dimitris A Buschman, Timothy J Miller, Earl K Working Memory Load Modulates Neuronal Coupling |
| title | Working Memory Load Modulates Neuronal Coupling |
| title_full | Working Memory Load Modulates Neuronal Coupling |
| title_fullStr | Working Memory Load Modulates Neuronal Coupling |
| title_full_unstemmed | Working Memory Load Modulates Neuronal Coupling |
| title_short | Working Memory Load Modulates Neuronal Coupling |
| title_sort | working memory load modulates neuronal coupling |
| url | https://hdl.handle.net/1721.1/135795 |
| work_keys_str_mv | AT pinotsisdimitrisa workingmemoryloadmodulatesneuronalcoupling AT buschmantimothyj workingmemoryloadmodulatesneuronalcoupling AT millerearlk workingmemoryloadmodulatesneuronalcoupling |