Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Optical monitoring of blood glucose levels for non-invasive diagnosis is a growing area of research. Recent efforts in this direction have been inclined towards reducing the requirement of calibration framework. Here, we are presenting a...

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Bibliographic Details
Main Authors: Singh, Surya P, Mukherjee, Soumavo, Galindo, Luis H, So, Peter TC, Dasari, Ramachandra Rao, Khan, Uzma Zubair, Kannan, Raghuraman, Upendran, Anandhi, Kang, Jeon Woong
Other Authors: Massachusetts Institute of Technology. Laser Biomedical Research Center
Format: Article
Language:English
Published: Springer Nature 2021
Online Access:https://hdl.handle.net/1721.1/135824
Description
Summary:© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Optical monitoring of blood glucose levels for non-invasive diagnosis is a growing area of research. Recent efforts in this direction have been inclined towards reducing the requirement of calibration framework. Here, we are presenting a systematic investigation on the influence of variation in the ratio of calibration and validation points on the prospective predictive accuracy of spectral models. A fiber-optic probe coupled Raman system has been employed for transcutaneous measurements. Limit of agreement analysis between serum and partial least square regression predicted spectroscopic glucose values has been performed for accurate comparison. Findings are suggestive of strong predictive accuracy of spectroscopic models without requiring substantive calibration measurements. [Figure not available: see fulltext.].

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