Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization
© 2018 Elsevier Inc. The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135844 |
| _version_ | 1826195368622161920 |
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| author | Kelly, Sean M Raudales, Ricardo He, Miao Lee, Jannifer H Kim, Yongsoo Gibb, Leif G Wu, Priscilla Matho, Katherine Osten, Pavel Graybiel, Ann M Huang, Z Josh |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Kelly, Sean M Raudales, Ricardo He, Miao Lee, Jannifer H Kim, Yongsoo Gibb, Leif G Wu, Priscilla Matho, Katherine Osten, Pavel Graybiel, Ann M Huang, Z Josh |
| author_sort | Kelly, Sean M |
| collection | MIT |
| description | © 2018 Elsevier Inc. The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of these organizations and their developmental relationships are unknown, leaving a conceptual gap in understanding the cortico-basal ganglia system. Through genetic fate mapping, we demonstrate that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitors (IPs). The early phase of this program produces striosomal spiny projection neurons (SPNs) through fate-restricted apical IPs (aIP S s) with limited capacity; the late phase produces matrix SPNs through fate-restricted basal IPs (bIP M s) with expanded capacity. Notably, direct and indirect pathway SPNs arise within both aIP S and bIP M pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry. In this article, Kelly et al. describe a lineage program embedded in lateral ganglionic eminence progenitors responsible for striosome-matrix compartmentalization in striatum. |
| first_indexed | 2024-09-23T10:11:34Z |
| format | Article |
| id | mit-1721.1/135844 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:11:34Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1358442023-12-08T21:39:18Z Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization Kelly, Sean M Raudales, Ricardo He, Miao Lee, Jannifer H Kim, Yongsoo Gibb, Leif G Wu, Priscilla Matho, Katherine Osten, Pavel Graybiel, Ann M Huang, Z Josh McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences © 2018 Elsevier Inc. The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of these organizations and their developmental relationships are unknown, leaving a conceptual gap in understanding the cortico-basal ganglia system. Through genetic fate mapping, we demonstrate that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitors (IPs). The early phase of this program produces striosomal spiny projection neurons (SPNs) through fate-restricted apical IPs (aIP S s) with limited capacity; the late phase produces matrix SPNs through fate-restricted basal IPs (bIP M s) with expanded capacity. Notably, direct and indirect pathway SPNs arise within both aIP S and bIP M pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry. In this article, Kelly et al. describe a lineage program embedded in lateral ganglionic eminence progenitors responsible for striosome-matrix compartmentalization in striatum. 2021-10-27T20:29:36Z 2021-10-27T20:29:36Z 2018 2019-10-01T17:56:29Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135844 en 10.1016/J.NEURON.2018.06.021 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Kelly, Sean M Raudales, Ricardo He, Miao Lee, Jannifer H Kim, Yongsoo Gibb, Leif G Wu, Priscilla Matho, Katherine Osten, Pavel Graybiel, Ann M Huang, Z Josh Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title | Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title_full | Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title_fullStr | Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title_full_unstemmed | Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title_short | Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization |
| title_sort | radial glial lineage progression and differential intermediate progenitor amplification underlie striatal compartments and circuit organization |
| url | https://hdl.handle.net/1721.1/135844 |
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