Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

© 2019 American Association for Cancer Research. Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug resistance. Despite the important association of tumor microenvironment ac...

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Bibliographic Details
Main Authors: Rohani, Nazanin, Hao, Liangliang, Alexis, Maria S, Joughin, Brian A, Krismer, Konstantin, Moufarrej, Mira N, Soltis, Anthony R, Lauffenburger, Douglas A, Yaffe, Michael B, Burge, Christopher B, Bhatia, Sangeeta N, Gertler, Frank B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: American Association for Cancer Research (AACR) 2021
Online Access:https://hdl.handle.net/1721.1/135868

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