Representation of visual landmarks in retrosplenial cortex
© Fischer et al. The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavio...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications, Ltd
2021
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| Online Access: | https://hdl.handle.net/1721.1/135945 |
| _version_ | 1826213727452528640 |
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| author | Fischer, Lukas F Mojica Soto-Albors, Raul Buck, Friederike Harnett, Mark T |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Fischer, Lukas F Mojica Soto-Albors, Raul Buck, Friederike Harnett, Mark T |
| author_sort | Fischer, Lukas F |
| collection | MIT |
| description | © Fischer et al. The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information. |
| first_indexed | 2024-09-23T15:53:51Z |
| format | Article |
| id | mit-1721.1/135945 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:53:51Z |
| publishDate | 2021 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | dspace |
| spelling | mit-1721.1/1359452023-01-11T19:53:18Z Representation of visual landmarks in retrosplenial cortex Fischer, Lukas F Mojica Soto-Albors, Raul Buck, Friederike Harnett, Mark T Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT © Fischer et al. The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information. 2021-10-27T20:30:04Z 2021-10-27T20:30:04Z 2020 2021-03-19T14:15:54Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135945 en 10.7554/ELIFE.51458 eLife Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd eLife |
| spellingShingle | Fischer, Lukas F Mojica Soto-Albors, Raul Buck, Friederike Harnett, Mark T Representation of visual landmarks in retrosplenial cortex |
| title | Representation of visual landmarks in retrosplenial cortex |
| title_full | Representation of visual landmarks in retrosplenial cortex |
| title_fullStr | Representation of visual landmarks in retrosplenial cortex |
| title_full_unstemmed | Representation of visual landmarks in retrosplenial cortex |
| title_short | Representation of visual landmarks in retrosplenial cortex |
| title_sort | representation of visual landmarks in retrosplenial cortex |
| url | https://hdl.handle.net/1721.1/135945 |
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