Quantitative analysis of Y-Chromosome gene expression across 36 human tissues
© 2020 Godfrey et al. Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cold Spring Harbor Laboratory
2021
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| Online Access: | https://hdl.handle.net/1721.1/136020 |
| _version_ | 1811086080001179648 |
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| author | Godfrey, Alexander K Naqvi, Sahin Chmátal, Lukáš Chick, Joel M Mitchell, Richard N Gygi, Steven P Skaletsky, Helen Page, David C |
| author_facet | Godfrey, Alexander K Naqvi, Sahin Chmátal, Lukáš Chick, Joel M Mitchell, Richard N Gygi, Steven P Skaletsky, Helen Page, David C |
| author_sort | Godfrey, Alexander K |
| collection | MIT |
| description | © 2020 Godfrey et al. Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundreds of individuals. Although it is often said that Y-Chromosome genes are lowly expressed outside the testis, we report many instances of elevated Y-Chromosome gene expression in a nonreproductive tissue. A notable example is EIF1AY, which encodes eukaryotic translation initiation factor 1A Y-linked, together with its Xlinked homolog EIF1AX. Evolutionary loss of a Y-linked microRNA target site enabled up-regulation of EIF1AY, but not of EIF1AX, in the heart. Consequently, this essential translation initiation factor is nearly twice as abundant in male as in female heart tissue at the protein level. Divergence between the X and Y Chromosomes in regulatory sequence can therefore lead to tissue-specific Y-Chromosome-driven sex biases in expression of critical, dosage-sensitive regulatory genes. |
| first_indexed | 2024-09-23T13:20:34Z |
| format | Article |
| id | mit-1721.1/136020 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:20:34Z |
| publishDate | 2021 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | dspace |
| spelling | mit-1721.1/1360202021-10-28T03:53:36Z Quantitative analysis of Y-Chromosome gene expression across 36 human tissues Godfrey, Alexander K Naqvi, Sahin Chmátal, Lukáš Chick, Joel M Mitchell, Richard N Gygi, Steven P Skaletsky, Helen Page, David C © 2020 Godfrey et al. Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundreds of individuals. Although it is often said that Y-Chromosome genes are lowly expressed outside the testis, we report many instances of elevated Y-Chromosome gene expression in a nonreproductive tissue. A notable example is EIF1AY, which encodes eukaryotic translation initiation factor 1A Y-linked, together with its Xlinked homolog EIF1AX. Evolutionary loss of a Y-linked microRNA target site enabled up-regulation of EIF1AY, but not of EIF1AX, in the heart. Consequently, this essential translation initiation factor is nearly twice as abundant in male as in female heart tissue at the protein level. Divergence between the X and Y Chromosomes in regulatory sequence can therefore lead to tissue-specific Y-Chromosome-driven sex biases in expression of critical, dosage-sensitive regulatory genes. 2021-10-27T20:30:26Z 2021-10-27T20:30:26Z 2020 2021-07-21T17:45:40Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136020 en 10.1101/GR.261248.120 Genome Research Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory Press |
| spellingShingle | Godfrey, Alexander K Naqvi, Sahin Chmátal, Lukáš Chick, Joel M Mitchell, Richard N Gygi, Steven P Skaletsky, Helen Page, David C Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title | Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title_full | Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title_fullStr | Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title_full_unstemmed | Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title_short | Quantitative analysis of Y-Chromosome gene expression across 36 human tissues |
| title_sort | quantitative analysis of y chromosome gene expression across 36 human tissues |
| url | https://hdl.handle.net/1721.1/136020 |
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