Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

© 2020 The Authors Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth of tumors but often leads to the emergence of slowly dividing persister cells, which constitute a reservoir for the selection of drug-resistant clones. In BRAFV600E melanomas, RAF and MEK...

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Bibliographic Details
Main Authors: Gerosa, Luca, Chidley, Christopher, Fröhlich, Fabian, Sanchez, Gabriela, Lim, Sang Kyun, Muhlich, Jeremy, Chen, Jia-Yun, Vallabhaneni, Sreeram, Baker, Gregory J, Schapiro, Denis, Atanasova, Mariya I, Chylek, Lily A, Shi, Tujin, Yi, Lian, Nicora, Carrie D, Claas, Allison, Ng, Thomas SC, Kohler, Rainer H, Lauffenburger, Douglas A, Weissleder, Ralph, Miller, Miles A, Qian, Wei-Jun, Wiley, H Steven, Sorger, Peter K
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/136137

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