Dissecting the antibody-OME: past, present, and future
© 2020 The Authors Humoral immunity is key to protection for nearly all licensed vaccines. Yet, the design of vaccines has been more difficult for some of our most deadly killers (e.g. HIV, influenza, Dengue virus, etc.), likely due to our incomplete understanding of the precise immunological mechan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/136164 |
| _version_ | 1826198704178069504 |
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| author | Loos, Carolin Lauffenburger, Douglas A Alter, Galit |
| author_facet | Loos, Carolin Lauffenburger, Douglas A Alter, Galit |
| author_sort | Loos, Carolin |
| collection | MIT |
| description | © 2020 The Authors Humoral immunity is key to protection for nearly all licensed vaccines. Yet, the design of vaccines has been more difficult for some of our most deadly killers (e.g. HIV, influenza, Dengue virus, etc.), likely due to our incomplete understanding of the precise immunological mechanisms associated with protection. Humoral immunity is governed both by B-cells and their bi-functional secreted antibodies, all of which have a unique capacity to evolve during an immune response. Current OMIC technologies capture individual features of the humoral immune response, providing a glimpse into humoral components (Fab/Fc/B-cell-omic), but fail to provide a wholistic view of the humoral response as a collective functional arm. Here, we dissect current OMIC strategies reviewing experimental and computational approaches, that if integrated could provide a true systems-level view of the humoral immune response. |
| first_indexed | 2024-09-23T11:08:48Z |
| format | Article |
| id | mit-1721.1/136164 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:08:48Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1361642021-10-28T04:21:40Z Dissecting the antibody-OME: past, present, and future Loos, Carolin Lauffenburger, Douglas A Alter, Galit © 2020 The Authors Humoral immunity is key to protection for nearly all licensed vaccines. Yet, the design of vaccines has been more difficult for some of our most deadly killers (e.g. HIV, influenza, Dengue virus, etc.), likely due to our incomplete understanding of the precise immunological mechanisms associated with protection. Humoral immunity is governed both by B-cells and their bi-functional secreted antibodies, all of which have a unique capacity to evolve during an immune response. Current OMIC technologies capture individual features of the humoral immune response, providing a glimpse into humoral components (Fab/Fc/B-cell-omic), but fail to provide a wholistic view of the humoral response as a collective functional arm. Here, we dissect current OMIC strategies reviewing experimental and computational approaches, that if integrated could provide a true systems-level view of the humoral immune response. 2021-10-27T20:31:11Z 2021-10-27T20:31:11Z 2020 2021-09-07T17:00:20Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136164 en 10.1016/J.COI.2020.06.003 Current Opinion in Immunology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Loos, Carolin Lauffenburger, Douglas A Alter, Galit Dissecting the antibody-OME: past, present, and future |
| title | Dissecting the antibody-OME: past, present, and future |
| title_full | Dissecting the antibody-OME: past, present, and future |
| title_fullStr | Dissecting the antibody-OME: past, present, and future |
| title_full_unstemmed | Dissecting the antibody-OME: past, present, and future |
| title_short | Dissecting the antibody-OME: past, present, and future |
| title_sort | dissecting the antibody ome past present and future |
| url | https://hdl.handle.net/1721.1/136164 |
| work_keys_str_mv | AT looscarolin dissectingtheantibodyomepastpresentandfuture AT lauffenburgerdouglasa dissectingtheantibodyomepastpresentandfuture AT altergalit dissectingtheantibodyomepastpresentandfuture |