Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits

Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits

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© 2020, The Author(s). CACNA1I, a schizophrenia risk gene, encodes a subtype of voltage-gated T-type calcium channel CaV3.3. We previously reported that a patient-derived missense de novo mutation (R1346H) of CACNA1I impaired CaV3.3 channel function. Here, we generated CaV3.3-RH knock-in animals, al...

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Bibliographic Details
Main Authors: Ghoshal, Ayan, Uygun, David S, Yang, Lingling, McNally, James M, Lopez-Huerta, Violeta G, Arias-Garcia, Mario A, Baez-Nieto, David, Allen, Andrew, Fitzgerald, Megan, Choi, Soonwook, Zhang, Qiangge, Hope, Jen M, Yan, Karena, Mao, Xiaohong, Nicholson, Thomas B, Imaizumi, Kazuo, Fu, Zhanyan, Feng, Guoping, Brown, Ritchie E, Strecker, Robert E, Purcell, Shaun M, Pan, Jen Q
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/136233

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