The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

© 2020 National Academy of Sciences. All rights reserved. Small molecules can affect many cellular processes. The disambiguation of these effects to identify the causative mechanisms of cell death is extremely challenging. This challenge impacts both clinical development and the interpretation of ch...

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Bibliographic Details
Main Authors: Bruno, Peter M, Lu, Mengrou, Dennis, Kady A, Inam, Haider, Moore, Connor J, Sheehe, John, Elledge, Stephen J, Hemann, Michael T, Pritchard, Justin R
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/136236

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