mTOR at the nexus of nutrition, growth, ageing and disease
© 2020, Springer Nature Limited. The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls bio...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/136262 |
| _version_ | 1826189278135189504 |
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| author | Liu, Grace Y Sabatini, David M |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Liu, Grace Y Sabatini, David M |
| author_sort | Liu, Grace Y |
| collection | MIT |
| description | © 2020, Springer Nature Limited. The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. |
| first_indexed | 2024-09-23T08:12:37Z |
| format | Article |
| id | mit-1721.1/136262 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:12:37Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1362622023-12-13T21:51:22Z mTOR at the nexus of nutrition, growth, ageing and disease Liu, Grace Y Sabatini, David M Massachusetts Institute of Technology. Department of Biology Howard Hughes Medical Institute Whitehead Institute for Biomedical Research Koch Institute for Integrative Cancer Research at MIT © 2020, Springer Nature Limited. The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. 2021-10-27T20:34:35Z 2021-10-27T20:34:35Z 2020 2021-07-23T18:12:44Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136262 en 10.1038/S41580-019-0199-Y Nature Reviews Molecular Cell Biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Liu, Grace Y Sabatini, David M mTOR at the nexus of nutrition, growth, ageing and disease |
| title | mTOR at the nexus of nutrition, growth, ageing and disease |
| title_full | mTOR at the nexus of nutrition, growth, ageing and disease |
| title_fullStr | mTOR at the nexus of nutrition, growth, ageing and disease |
| title_full_unstemmed | mTOR at the nexus of nutrition, growth, ageing and disease |
| title_short | mTOR at the nexus of nutrition, growth, ageing and disease |
| title_sort | mtor at the nexus of nutrition growth ageing and disease |
| url | https://hdl.handle.net/1721.1/136262 |
| work_keys_str_mv | AT liugracey mtoratthenexusofnutritiongrowthageinganddisease AT sabatinidavidm mtoratthenexusofnutritiongrowthageinganddisease |