The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Powerful experimental tools have contributed a wealth of novel insight into cancer etiology from the organ to the subcellular levels. However, these advances in understanding have outpaced improvements in clinical outc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/136279 |
| _version_ | 1826189804895731712 |
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| author | Coughlin, Mark F Kamm, Roger D |
| author_facet | Coughlin, Mark F Kamm, Roger D |
| author_sort | Coughlin, Mark F |
| collection | MIT |
| description | © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Powerful experimental tools have contributed a wealth of novel insight into cancer etiology from the organ to the subcellular levels. However, these advances in understanding have outpaced improvements in clinical outcomes. One possible reason for this shortcoming is the reliance on animal models that do not fully replicate human physiology. An alternative in vitro approach that has recently emerged features engineered microfluidic platforms to investigate cancer progression. These devices allow precise control over cellular components, extracellular constituents, and physical forces, while facilitating detailed microscopic analysis of the metastatic process. This review focuses on the recent use of microfluidic platforms to investigate the mechanism of cancer cell extravasation. |
| first_indexed | 2024-09-23T08:23:30Z |
| format | Article |
| id | mit-1721.1/136279 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:23:30Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1362792021-10-28T04:58:35Z The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation Coughlin, Mark F Kamm, Roger D © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Powerful experimental tools have contributed a wealth of novel insight into cancer etiology from the organ to the subcellular levels. However, these advances in understanding have outpaced improvements in clinical outcomes. One possible reason for this shortcoming is the reliance on animal models that do not fully replicate human physiology. An alternative in vitro approach that has recently emerged features engineered microfluidic platforms to investigate cancer progression. These devices allow precise control over cellular components, extracellular constituents, and physical forces, while facilitating detailed microscopic analysis of the metastatic process. This review focuses on the recent use of microfluidic platforms to investigate the mechanism of cancer cell extravasation. 2021-10-27T20:34:41Z 2021-10-27T20:34:41Z 2020 2020-08-17T16:19:22Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136279 en 10.1002/ADHM.201901410 Advanced Healthcare Materials Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Coughlin, Mark F Kamm, Roger D The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title | The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title_full | The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title_fullStr | The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title_full_unstemmed | The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title_short | The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation |
| title_sort | use of microfluidic platforms to probe the mechanism of cancer cell extravasation |
| url | https://hdl.handle.net/1721.1/136279 |
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