Keeping the Proportions of Protein Complex Components in Check
© 2020 The Authors How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribos...
| Príomhchruthaitheoirí: | , , , , |
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| Rannpháirtithe: | |
| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Elsevier BV
2021
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| Rochtain ar líne: | https://hdl.handle.net/1721.1/136292 |
| _version_ | 1826194405655052288 |
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| author | Taggart, James Christopher Zauber, Henrik Selbach, Matthias Li, Gene-Wei McShane, Erik |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Taggart, James Christopher Zauber, Henrik Selbach, Matthias Li, Gene-Wei McShane, Erik |
| author_sort | Taggart, James Christopher |
| collection | MIT |
| description | © 2020 The Authors How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation. |
| first_indexed | 2024-09-23T09:55:36Z |
| format | Article |
| id | mit-1721.1/136292 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:55:36Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1362922023-02-24T20:02:09Z Keeping the Proportions of Protein Complex Components in Check Taggart, James Christopher Zauber, Henrik Selbach, Matthias Li, Gene-Wei McShane, Erik Massachusetts Institute of Technology. Department of Biology © 2020 The Authors How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation. 2021-10-27T20:34:45Z 2021-10-27T20:34:45Z 2020 2021-07-21T14:56:14Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136292 en 10.1016/J.CELS.2020.01.004 Cell Systems Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Taggart, James Christopher Zauber, Henrik Selbach, Matthias Li, Gene-Wei McShane, Erik Keeping the Proportions of Protein Complex Components in Check |
| title | Keeping the Proportions of Protein Complex Components in Check |
| title_full | Keeping the Proportions of Protein Complex Components in Check |
| title_fullStr | Keeping the Proportions of Protein Complex Components in Check |
| title_full_unstemmed | Keeping the Proportions of Protein Complex Components in Check |
| title_short | Keeping the Proportions of Protein Complex Components in Check |
| title_sort | keeping the proportions of protein complex components in check |
| url | https://hdl.handle.net/1721.1/136292 |
| work_keys_str_mv | AT taggartjameschristopher keepingtheproportionsofproteincomplexcomponentsincheck AT zauberhenrik keepingtheproportionsofproteincomplexcomponentsincheck AT selbachmatthias keepingtheproportionsofproteincomplexcomponentsincheck AT ligenewei keepingtheproportionsofproteincomplexcomponentsincheck AT mcshaneerik keepingtheproportionsofproteincomplexcomponentsincheck |