Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

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© 2020, eLife Sciences Publications Ltd. All rights reserved. ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and translocates specific protein substrates into the degradation chamber of ClpP. We present cryo-EM studies of the E. coli enzyme that show how asymmetric h...

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Bibliographic Details
Main Authors: Fei, Xue, Bell, Tristan A, Jenni, Simon, Stinson, Benjamin M, Baker, Tania A, Harrison, Stephen C, Sauer, Robert T
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2021
Online Access:https://hdl.handle.net/1721.1/136296

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