Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/136309 |
| _version_ | 1826195265126662144 |
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| author | Yu, Jicheng Wang, Jinqiang Zhang, Yuqi Chen, Guojun Mao, Weiwei Ye, Yanqi Kahkoska, Anna R Buse, John B Langer, Robert Gu, Zhen |
| author_facet | Yu, Jicheng Wang, Jinqiang Zhang, Yuqi Chen, Guojun Mao, Weiwei Ye, Yanqi Kahkoska, Anna R Buse, John B Langer, Robert Gu, Zhen |
| author_sort | Yu, Jicheng |
| collection | MIT |
| description | © 2020, The Author(s), under exclusive licence to Springer Nature Limited. Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin delivery systems with rapid in vivo glucose-responsive behaviour typically have limited insulin-loading capacities and cannot be manufactured easily. Here, we show that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs (for minipigs >25 kg, glucose regulation lasted >20 h with patches of ~5 cm2). Under hyperglycaemic conditions, phenylboronic acid units within the polymeric matrix reversibly form glucose–boronate complexes that—owing to their increased negative charge—induce the swelling of the polymeric matrix and weaken the electrostatic interactions between the negatively charged insulin and polymers, promoting the rapid release of insulin. This proof-of-concept demonstration may aid the development of other translational stimuli-responsive microneedle patches for drug delivery. |
| first_indexed | 2024-09-23T10:09:58Z |
| format | Article |
| id | mit-1721.1/136309 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:09:58Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1363092021-10-28T04:34:19Z Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs Yu, Jicheng Wang, Jinqiang Zhang, Yuqi Chen, Guojun Mao, Weiwei Ye, Yanqi Kahkoska, Anna R Buse, John B Langer, Robert Gu, Zhen © 2020, The Author(s), under exclusive licence to Springer Nature Limited. Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin delivery systems with rapid in vivo glucose-responsive behaviour typically have limited insulin-loading capacities and cannot be manufactured easily. Here, we show that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs (for minipigs >25 kg, glucose regulation lasted >20 h with patches of ~5 cm2). Under hyperglycaemic conditions, phenylboronic acid units within the polymeric matrix reversibly form glucose–boronate complexes that—owing to their increased negative charge—induce the swelling of the polymeric matrix and weaken the electrostatic interactions between the negatively charged insulin and polymers, promoting the rapid release of insulin. This proof-of-concept demonstration may aid the development of other translational stimuli-responsive microneedle patches for drug delivery. 2021-10-27T20:34:49Z 2021-10-27T20:34:49Z 2020 2021-06-14T14:10:06Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136309 en 10.1038/S41551-019-0508-Y Nature Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Yu, Jicheng Wang, Jinqiang Zhang, Yuqi Chen, Guojun Mao, Weiwei Ye, Yanqi Kahkoska, Anna R Buse, John B Langer, Robert Gu, Zhen Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title | Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title_full | Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title_fullStr | Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title_full_unstemmed | Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title_short | Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| title_sort | glucose responsive insulin patch for the regulation of blood glucose in mice and minipigs |
| url | https://hdl.handle.net/1721.1/136309 |
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