Light-degradable hydrogels as dynamic triggers for gastrointestinal applications
Copyright © 2020 The Authors Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe the development of a modular and tun...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/136311 |
| _version_ | 1826216797568761856 |
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| author | Raman, Ritu Hua, Tiffany Gwynne, Declan Collins, Joy Tamang, Siddartha Zhou, Jianlin Esfandiary, Tina Soares, Vance Pajovic, Simo Hayward, Alison Langer, Robert Traverso, Giovanni |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Raman, Ritu Hua, Tiffany Gwynne, Declan Collins, Joy Tamang, Siddartha Zhou, Jianlin Esfandiary, Tina Soares, Vance Pajovic, Simo Hayward, Alison Langer, Robert Traverso, Giovanni |
| author_sort | Raman, Ritu |
| collection | MIT |
| description | Copyright © 2020 The Authors Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe the development of a modular and tunable light-triggerable hydrogel system capable of interfacing with implantable devices. We apply these materials to two applications in the gastrointestinal (GI) tract: a bariatric balloon and an esophageal stent. We demonstrate biocompatibility and on-demand triggering of the material in vitro, ex vivo, and in vivo. Moreover, we characterize performance of the system in a porcine large animal model with an accompanying ingestible LED. Light-triggerable hydrogels have the potential to be applied broadly throughout the GI tract and other anatomic areas. By demonstrating the first use of light-degradable hydrogels in vivo, we provide biomedical engineers and clinicians with a previously unavailable, safe, dynamically deliverable, and precise tool to design dynamically actuated implantable devices. |
| first_indexed | 2024-09-23T16:53:16Z |
| format | Article |
| id | mit-1721.1/136311 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:53:16Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1363112023-11-07T19:58:09Z Light-degradable hydrogels as dynamic triggers for gastrointestinal applications Raman, Ritu Hua, Tiffany Gwynne, Declan Collins, Joy Tamang, Siddartha Zhou, Jianlin Esfandiary, Tina Soares, Vance Pajovic, Simo Hayward, Alison Langer, Robert Traverso, Giovanni Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Division of Comparative Medicine Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Copyright © 2020 The Authors Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe the development of a modular and tunable light-triggerable hydrogel system capable of interfacing with implantable devices. We apply these materials to two applications in the gastrointestinal (GI) tract: a bariatric balloon and an esophageal stent. We demonstrate biocompatibility and on-demand triggering of the material in vitro, ex vivo, and in vivo. Moreover, we characterize performance of the system in a porcine large animal model with an accompanying ingestible LED. Light-triggerable hydrogels have the potential to be applied broadly throughout the GI tract and other anatomic areas. By demonstrating the first use of light-degradable hydrogels in vivo, we provide biomedical engineers and clinicians with a previously unavailable, safe, dynamically deliverable, and precise tool to design dynamically actuated implantable devices. 2021-10-27T20:34:50Z 2021-10-27T20:34:50Z 2020 2021-06-22T15:14:25Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136311 en 10.1126/SCIADV.AAY0065 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Raman, Ritu Hua, Tiffany Gwynne, Declan Collins, Joy Tamang, Siddartha Zhou, Jianlin Esfandiary, Tina Soares, Vance Pajovic, Simo Hayward, Alison Langer, Robert Traverso, Giovanni Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title | Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title_full | Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title_fullStr | Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title_full_unstemmed | Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title_short | Light-degradable hydrogels as dynamic triggers for gastrointestinal applications |
| title_sort | light degradable hydrogels as dynamic triggers for gastrointestinal applications |
| url | https://hdl.handle.net/1721.1/136311 |
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