Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC)
© 2017 International Society for Magnetic Resonance in Medicine Purpose: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) is a recent technique that measures voxel-wise oxygen extraction fraction (OEF) but suffers from long scan times, limiting its application. We imple...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021
|
| Online Access: | https://hdl.handle.net/1721.1/136336 |
| _version_ | 1826197081403949056 |
|---|---|
| author | Stout, Jeffrey N Adalsteinsson, Elfar Rosen, Bruce R Bolar, Divya S |
| author_facet | Stout, Jeffrey N Adalsteinsson, Elfar Rosen, Bruce R Bolar, Divya S |
| author_sort | Stout, Jeffrey N |
| collection | MIT |
| description | © 2017 International Society for Magnetic Resonance in Medicine Purpose: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) is a recent technique that measures voxel-wise oxygen extraction fraction (OEF) but suffers from long scan times, limiting its application. We implemented multiecho QUIXOTIC dubbed turbo QUIXOTIC (tQUIXOTIC) that reduces scan time eightfold and then applied it in functional MRI. Methods: tQUIXOTIC utilizes a novel turbo gradient spin echo readout enabling measurement of venular blood transverse relaxation rate in a single tag-control acquisition. Using tQUIXOTIC, we estimated cortical gray matter (GM) OEF, created voxel-by-voxel GM OEF maps, and quantified changes in visual cortex OEF during a blocked design flashing checkerboard visual stimulus. Contamination from cerebrospinal fluid partial volume averaging was estimated and corrected. Results: The average cortical GM OEF was estimated as 0.38 ± 0.06 (n = 8) using a 3.4-min acquisition. The average OEF in the visual cortex was estimated as 0.43 ± 0.04 at baseline and 0.35 ± 0.05 during activation, with an average %ΔOEF of −20%. These values are consistent with those of past studies. Conclusion: tQUIXOTIC successfully estimated cortical GM OEF in clinical scan times and detected changes in OEF during blocked design visual stimulation. tQUIXOTIC will be useful to monitor regional OEF clinically and in blocked design or event-related functional MRI experiments. Magn Reson Med 79:2713–2723, 2018. © 2017 International Society for Magnetic Resonance in Medicine. |
| first_indexed | 2024-09-23T10:42:10Z |
| format | Article |
| id | mit-1721.1/136336 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:42:10Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1363362022-04-01T16:26:06Z Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) Stout, Jeffrey N Adalsteinsson, Elfar Rosen, Bruce R Bolar, Divya S © 2017 International Society for Magnetic Resonance in Medicine Purpose: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) is a recent technique that measures voxel-wise oxygen extraction fraction (OEF) but suffers from long scan times, limiting its application. We implemented multiecho QUIXOTIC dubbed turbo QUIXOTIC (tQUIXOTIC) that reduces scan time eightfold and then applied it in functional MRI. Methods: tQUIXOTIC utilizes a novel turbo gradient spin echo readout enabling measurement of venular blood transverse relaxation rate in a single tag-control acquisition. Using tQUIXOTIC, we estimated cortical gray matter (GM) OEF, created voxel-by-voxel GM OEF maps, and quantified changes in visual cortex OEF during a blocked design flashing checkerboard visual stimulus. Contamination from cerebrospinal fluid partial volume averaging was estimated and corrected. Results: The average cortical GM OEF was estimated as 0.38 ± 0.06 (n = 8) using a 3.4-min acquisition. The average OEF in the visual cortex was estimated as 0.43 ± 0.04 at baseline and 0.35 ± 0.05 during activation, with an average %ΔOEF of −20%. These values are consistent with those of past studies. Conclusion: tQUIXOTIC successfully estimated cortical GM OEF in clinical scan times and detected changes in OEF during blocked design visual stimulation. tQUIXOTIC will be useful to monitor regional OEF clinically and in blocked design or event-related functional MRI experiments. Magn Reson Med 79:2713–2723, 2018. © 2017 International Society for Magnetic Resonance in Medicine. 2021-10-27T20:34:55Z 2021-10-27T20:34:55Z 2018 2019-05-01T16:20:40Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136336 en 10.1002/MRM.26947 Magnetic Resonance in Medicine Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Stout, Jeffrey N Adalsteinsson, Elfar Rosen, Bruce R Bolar, Divya S Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title | Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title_full | Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title_fullStr | Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title_full_unstemmed | Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title_short | Functional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC) |
| title_sort | functional oxygen extraction fraction oef imaging with turbo gradient spin echo quixotic turbo quixotic |
| url | https://hdl.handle.net/1721.1/136336 |
| work_keys_str_mv | AT stoutjeffreyn functionaloxygenextractionfractionoefimagingwithturbogradientspinechoquixoticturboquixotic AT adalsteinssonelfar functionaloxygenextractionfractionoefimagingwithturbogradientspinechoquixoticturboquixotic AT rosenbrucer functionaloxygenextractionfractionoefimagingwithturbogradientspinechoquixoticturboquixotic AT bolardivyas functionaloxygenextractionfractionoefimagingwithturbogradientspinechoquixoticturboquixotic |