Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/136420 |
| _version_ | 1826204218176831488 |
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| author | Stowell, Rianne D Sipe, Grayson O Dawes, Ryan P Batchelor, Hanna N Lordy, Katheryn A Whitelaw, Brendan S Stoessel, Mark B Bidlack, Jean M Brown, Edward Sur, Mriganka Majewska, Ania K |
| author_facet | Stowell, Rianne D Sipe, Grayson O Dawes, Ryan P Batchelor, Hanna N Lordy, Katheryn A Whitelaw, Brendan S Stoessel, Mark B Bidlack, Jean M Brown, Edward Sur, Mriganka Majewska, Ania K |
| author_sort | Stowell, Rianne D |
| collection | MIT |
| description | © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis. However, the mechanisms that control surveillance and its role in synaptic plasticity are poorly understood. Microglial dynamics in vivo have been primarily studied in anesthetized animals. Here we report that microglial surveillance and injury response are reduced in awake mice as compared to anesthetized mice, suggesting that arousal state modulates microglial function. Pharmacologic stimulation of β2-adrenergic receptors recapitulated these observations and disrupted experience-dependent plasticity, and these effects required the presence of β2-adrenergic receptors in microglia. These results indicate that microglial roles in surveillance and synaptic plasticity in the mouse brain are modulated by noradrenergic tone fluctuations between arousal states and emphasize the need to understand the effect of disruptions of adrenergic signaling in neurodevelopment and neuropathology. |
| first_indexed | 2024-09-23T12:50:45Z |
| format | Article |
| id | mit-1721.1/136420 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:50:45Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1364202021-10-28T04:00:05Z Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex Stowell, Rianne D Sipe, Grayson O Dawes, Ryan P Batchelor, Hanna N Lordy, Katheryn A Whitelaw, Brendan S Stoessel, Mark B Bidlack, Jean M Brown, Edward Sur, Mriganka Majewska, Ania K © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis. However, the mechanisms that control surveillance and its role in synaptic plasticity are poorly understood. Microglial dynamics in vivo have been primarily studied in anesthetized animals. Here we report that microglial surveillance and injury response are reduced in awake mice as compared to anesthetized mice, suggesting that arousal state modulates microglial function. Pharmacologic stimulation of β2-adrenergic receptors recapitulated these observations and disrupted experience-dependent plasticity, and these effects required the presence of β2-adrenergic receptors in microglia. These results indicate that microglial roles in surveillance and synaptic plasticity in the mouse brain are modulated by noradrenergic tone fluctuations between arousal states and emphasize the need to understand the effect of disruptions of adrenergic signaling in neurodevelopment and neuropathology. 2021-10-27T20:35:17Z 2021-10-27T20:35:17Z 2019 2021-03-26T15:16:35Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136420 en 10.1038/S41593-019-0514-0 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Stowell, Rianne D Sipe, Grayson O Dawes, Ryan P Batchelor, Hanna N Lordy, Katheryn A Whitelaw, Brendan S Stoessel, Mark B Bidlack, Jean M Brown, Edward Sur, Mriganka Majewska, Ania K Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title_full | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title_fullStr | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title_full_unstemmed | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title_short | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| title_sort | noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
| url | https://hdl.handle.net/1721.1/136420 |
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