Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

© 2019 Elsevier Inc. Bacteriophage libraries containing millions of variants of phage tail fiber motifs on a common structural scaffold give rise to infectious phages with expanded or altered host ranges, which may be useful for phage therapy efforts.

Bibliographic Details
Main Authors: Yehl, Kevin, Lemire, Sébastien, Yang, Andrew C, Ando, Hiroki, Mimee, Mark, Torres, Marcelo Der Torossian, de la Fuente-Nunez, Cesar, Lu, Timothy K
Other Authors: Massachusetts Institute of Technology. Synthetic Biology Center
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/136451

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