Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

© 2019 American Association for the Advancement of Science. All rights reserved. The Rag guanosine triphosphatases (GTPases) recruit the master kinase mTORC1 to lysosomes to regulate cell growth and proliferation in response to amino acid availability. The nucleotide state of Rag heterodimers is cri...

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Bibliographic Details
Main Authors: Anandapadamanaban, Madhanagopal, Masson, Glenn R, Perisic, Olga, Berndt, Alex, Kaufman, Jonathan, Johnson, Chris M, Santhanam, Balaji, Rogala, Kacper B, Sabatini, David M, Williams, Roger L
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/136462

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