Delta oscillations phase limit neural activity during sevoflurane anesthesia
© 2019, The Author(s). Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general a...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/136571 |
| _version_ | 1826203054443069440 |
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| author | Chamadia, Shubham Pedemonte, Juan C Hahm, Eunice Y Mekonnen, Jennifer Ibala, Reine Gitlin, Jacob Ethridge, Breanna R Qu, Jason Vazquez, Rafael Rhee, James Liao, Erika T Brown, Emery N Akeju, Oluwaseun |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chamadia, Shubham Pedemonte, Juan C Hahm, Eunice Y Mekonnen, Jennifer Ibala, Reine Gitlin, Jacob Ethridge, Breanna R Qu, Jason Vazquez, Rafael Rhee, James Liao, Erika T Brown, Emery N Akeju, Oluwaseun |
| author_sort | Chamadia, Shubham |
| collection | MIT |
| description | © 2019, The Author(s). Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general anesthesia. This postulate remains unproven. Therefore, we performed a single-site, randomized, cross-over, high-density electroencephalogram study of sevoflurane and sevoflurane-plus-ketamine general anesthesia in 12 healthy subjects. Data were analyzed with multitaper spectral, global coherence, cross-frequency coupling, and phase-dependent methods. Our results suggest that coherent alpha oscillations are not fundamental for maintaining sevoflurane general anesthesia. Taken together, our results suggest that subanesthetic and general anesthetic sevoflurane brain states emerge from impaired information processing instantiated by a delta-higher frequency phase-amplitude coupling syntax. These results provide fundamental new insights into the neural circuit mechanisms of sevoflurane anesthesia and suggest that anesthetic states may be produced by extracranial perturbations that cause delta-higher frequency phase-amplitude interactions. |
| first_indexed | 2024-09-23T12:30:57Z |
| format | Article |
| id | mit-1721.1/136571 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:30:57Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1365712024-03-20T19:58:13Z Delta oscillations phase limit neural activity during sevoflurane anesthesia Chamadia, Shubham Pedemonte, Juan C Hahm, Eunice Y Mekonnen, Jennifer Ibala, Reine Gitlin, Jacob Ethridge, Breanna R Qu, Jason Vazquez, Rafael Rhee, James Liao, Erika T Brown, Emery N Akeju, Oluwaseun Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Institute for Medical Engineering & Science Picower Institute for Learning and Memory Massachusetts Institute of Technology. Institute for Data, Systems, and Society © 2019, The Author(s). Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general anesthesia. This postulate remains unproven. Therefore, we performed a single-site, randomized, cross-over, high-density electroencephalogram study of sevoflurane and sevoflurane-plus-ketamine general anesthesia in 12 healthy subjects. Data were analyzed with multitaper spectral, global coherence, cross-frequency coupling, and phase-dependent methods. Our results suggest that coherent alpha oscillations are not fundamental for maintaining sevoflurane general anesthesia. Taken together, our results suggest that subanesthetic and general anesthetic sevoflurane brain states emerge from impaired information processing instantiated by a delta-higher frequency phase-amplitude coupling syntax. These results provide fundamental new insights into the neural circuit mechanisms of sevoflurane anesthesia and suggest that anesthetic states may be produced by extracranial perturbations that cause delta-higher frequency phase-amplitude interactions. 2021-10-27T20:36:03Z 2021-10-27T20:36:03Z 2019 2021-03-29T14:29:46Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136571 en 10.1038/S42003-019-0664-3 Communications Biology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Chamadia, Shubham Pedemonte, Juan C Hahm, Eunice Y Mekonnen, Jennifer Ibala, Reine Gitlin, Jacob Ethridge, Breanna R Qu, Jason Vazquez, Rafael Rhee, James Liao, Erika T Brown, Emery N Akeju, Oluwaseun Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title | Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title_full | Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title_fullStr | Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title_full_unstemmed | Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title_short | Delta oscillations phase limit neural activity during sevoflurane anesthesia |
| title_sort | delta oscillations phase limit neural activity during sevoflurane anesthesia |
| url | https://hdl.handle.net/1721.1/136571 |
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