Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens
Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying the pathogen for patients to get the right treatment. Raman spectroscopy is...
| Main Authors: | , , , , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | https://hdl.handle.net/1721.1/136699 |
| _version_ | 1826216426823745536 |
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| author | Jia, Zixun Asiri, Sarah Elsharif, Asma Alamoudi, Widyan Al-Suhaimi, Ebtesam Kim, Sang-Gook |
| author_facet | Jia, Zixun Asiri, Sarah Elsharif, Asma Alamoudi, Widyan Al-Suhaimi, Ebtesam Kim, Sang-Gook |
| author_sort | Jia, Zixun |
| collection | MIT |
| description | Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying the pathogen for patients to get the right treatment. Raman spectroscopy is a promising candidate in pathogen diagnosis given its fast and label-free nature, only if the concentration of the pathogen is high enough to provide reasonable sensitivity. This work reports a new design of surface-enhanced Raman spectroscopy (SERS) substrate which will provide high enough sensitivity and fast and close contact of the target structure to the optical hot spots for immunomagnetic capturing-based bacteria-concentrating technique. The substrate uses inverted nanocone structure arrays made of transparent PDMS (Polydimethylsiloxane) to funnel the light from the bottom to the top of the cones where plasmonic gold nanorods are located. A high reflective and low loss layer is deposited on the outer surface of the cone. Given the geometry of cones, photons are multi-reflected by the outer layer and thus the number density of photons at hotspots increases by an order of magnitude, which could be high enough to detect immunomagnetically densified bacteria. |
| first_indexed | 2024-09-23T16:47:10Z |
| format | Article |
| id | mit-1721.1/136699 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:47:10Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1366992021-11-01T14:36:57Z Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens Jia, Zixun Asiri, Sarah Elsharif, Asma Alamoudi, Widyan Al-Suhaimi, Ebtesam Kim, Sang-Gook Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying the pathogen for patients to get the right treatment. Raman spectroscopy is a promising candidate in pathogen diagnosis given its fast and label-free nature, only if the concentration of the pathogen is high enough to provide reasonable sensitivity. This work reports a new design of surface-enhanced Raman spectroscopy (SERS) substrate which will provide high enough sensitivity and fast and close contact of the target structure to the optical hot spots for immunomagnetic capturing-based bacteria-concentrating technique. The substrate uses inverted nanocone structure arrays made of transparent PDMS (Polydimethylsiloxane) to funnel the light from the bottom to the top of the cones where plasmonic gold nanorods are located. A high reflective and low loss layer is deposited on the outer surface of the cone. Given the geometry of cones, photons are multi-reflected by the outer layer and thus the number density of photons at hotspots increases by an order of magnitude, which could be high enough to detect immunomagnetically densified bacteria. 2021-10-28T13:43:41Z 2021-10-28T13:43:41Z 2021-08-31 2021-09-09T13:39:32Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136699 Applied Sciences 11 (17): 8067 (2021) PUBLISHER_CC http://dx.doi.org/10.3390/app11178067 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Jia, Zixun Asiri, Sarah Elsharif, Asma Alamoudi, Widyan Al-Suhaimi, Ebtesam Kim, Sang-Gook Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title | Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title_full | Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title_fullStr | Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title_full_unstemmed | Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title_short | Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens |
| title_sort | design of inverted nano cone arrayed sers substrate for rapid detection of pathogens |
| url | https://hdl.handle.net/1721.1/136699 |
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