Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective
Abstract Coronaviruses COVID-19, SARS-CoV and NL63 use spikes in their corona to bind to angiotensin converting enzyme 2 (ACE2) sites on cytoskeletal membranes of host cells to deliver their viral payload. While groups such as disulfides in ACE2’s zinc metallopeptidase, and also in CO...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2022
|
| Online Access: | https://hdl.handle.net/1721.1/136850.2 |
| _version_ | 1826202595575726080 |
|---|---|
| author | Kolel-Veetil, Manoj Sen, Ayusman Buehler, Markus J. |
| author2 | Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics |
| author_facet | Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics Kolel-Veetil, Manoj Sen, Ayusman Buehler, Markus J. |
| author_sort | Kolel-Veetil, Manoj |
| collection | MIT |
| description | Abstract
Coronaviruses COVID-19, SARS-CoV and NL63 use spikes in their corona to bind to angiotensin converting enzyme 2 (ACE2) sites on cytoskeletal membranes of host cells to deliver their viral payload. While groups such as disulfides in ACE2’s zinc metallopeptidase, and also in COVID-19’s spikes, facilitate such binding, it is worth exploring how similar complementary sites on materials such as polymers, metals, ceramics, fabrics, and biomaterials promote binding of viruses and bacteria and how they could be further engineered to prevent bioactivity, or to act as agents to collect viral payloads in filters or similar devices. In that vein, this article offers a perspective on novel tools and approaches for chemically and topologically modifying most utilitarian surfaces via defensive topological vibrational engineering to either prevent such adhesion or to enhance adhesion and elicit vibrational characteristics/’musical signatures’ from the surfaces so that the structure of the binding sites of viruses and bacteria is permanently altered and/or their cellular machinery is permanently disabled by targeted chemical transformations.
Graphic abstract |
| first_indexed | 2024-09-23T12:10:09Z |
| format | Article |
| id | mit-1721.1/136850.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:10:09Z |
| publishDate | 2022 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/136850.22024-06-07T18:05:17Z Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective Kolel-Veetil, Manoj Sen, Ayusman Buehler, Markus J. Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics Abstract Coronaviruses COVID-19, SARS-CoV and NL63 use spikes in their corona to bind to angiotensin converting enzyme 2 (ACE2) sites on cytoskeletal membranes of host cells to deliver their viral payload. While groups such as disulfides in ACE2’s zinc metallopeptidase, and also in COVID-19’s spikes, facilitate such binding, it is worth exploring how similar complementary sites on materials such as polymers, metals, ceramics, fabrics, and biomaterials promote binding of viruses and bacteria and how they could be further engineered to prevent bioactivity, or to act as agents to collect viral payloads in filters or similar devices. In that vein, this article offers a perspective on novel tools and approaches for chemically and topologically modifying most utilitarian surfaces via defensive topological vibrational engineering to either prevent such adhesion or to enhance adhesion and elicit vibrational characteristics/’musical signatures’ from the surfaces so that the structure of the binding sites of viruses and bacteria is permanently altered and/or their cellular machinery is permanently disabled by targeted chemical transformations. Graphic abstract 2022-02-10T22:58:38Z 2021-11-01T14:33:47Z 2022-02-10T22:58:38Z 2021-06 2021-01 2021-07-01T04:11:17Z Article http://purl.org/eprint/type/JournalArticle 2059-8521 https://hdl.handle.net/1721.1/136850.2 en https://doi.org/10.1557/s43580-021-00079-0 MRS Advances Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply application/octet-stream Springer Science and Business Media LLC Springer International Publishing |
| spellingShingle | Kolel-Veetil, Manoj Sen, Ayusman Buehler, Markus J. Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title | Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title_full | Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title_fullStr | Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title_full_unstemmed | Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title_short | Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective |
| title_sort | surface adhesion of viruses and bacteria defend only and or vibrationally extinguish also a perspective |
| url | https://hdl.handle.net/1721.1/136850.2 |
| work_keys_str_mv | AT kolelveetilmanoj surfaceadhesionofvirusesandbacteriadefendonlyandorvibrationallyextinguishalsoaperspective AT senayusman surfaceadhesionofvirusesandbacteriadefendonlyandorvibrationallyextinguishalsoaperspective AT buehlermarkusj surfaceadhesionofvirusesandbacteriadefendonlyandorvibrationallyextinguishalsoaperspective |