Engineered neuromuscular actuators for medicine, meat, and machines
Abstract Movement is central to life. Neuromuscular tissues control voluntary movement in humans and many other living creatures, offering significant advantages in adaptability and robustness as compared to abiotic actuators. The impressive functional capabilities of neuromuscular...
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| Format: | Article |
| Language: | English |
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Springer International Publishing
2021
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| Online Access: | https://hdl.handle.net/1721.1/136857 |
| _version_ | 1826211679166267392 |
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| author | Raman, Ritu |
| author_facet | Raman, Ritu |
| author_sort | Raman, Ritu |
| collection | MIT |
| description | Abstract
Movement is central to life. Neuromuscular tissues control voluntary movement in humans and many other living creatures, offering significant advantages in adaptability and robustness as compared to abiotic actuators. The impressive functional capabilities of neuromuscular tissues have inspired researchers to attempt de novo synthesis of the biological motor system via tissue engineering. This article highlights key recent advances in tissue engineering skeletal muscle and discusses promising strategies to control engineered muscle via biological neural networks and abiotic soft electronic interfaces. Challenges associated with cell sourcing, biomaterials design, and scalable precision manufacturing, along with emerging strategies to address those challenges, are presented. Finally, we highlight how engineered neuromuscular tissues have enabled studying, controlling, and deploying them as actuators in a range of real-world applications including drug discovery, regenerative medicine, cellular agriculture, and soft robotics.
Graphic abstract |
| first_indexed | 2024-09-23T15:09:48Z |
| format | Article |
| id | mit-1721.1/136857 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:09:48Z |
| publishDate | 2021 |
| publisher | Springer International Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1368572021-11-02T03:08:25Z Engineered neuromuscular actuators for medicine, meat, and machines Raman, Ritu Abstract Movement is central to life. Neuromuscular tissues control voluntary movement in humans and many other living creatures, offering significant advantages in adaptability and robustness as compared to abiotic actuators. The impressive functional capabilities of neuromuscular tissues have inspired researchers to attempt de novo synthesis of the biological motor system via tissue engineering. This article highlights key recent advances in tissue engineering skeletal muscle and discusses promising strategies to control engineered muscle via biological neural networks and abiotic soft electronic interfaces. Challenges associated with cell sourcing, biomaterials design, and scalable precision manufacturing, along with emerging strategies to address those challenges, are presented. Finally, we highlight how engineered neuromuscular tissues have enabled studying, controlling, and deploying them as actuators in a range of real-world applications including drug discovery, regenerative medicine, cellular agriculture, and soft robotics. Graphic abstract 2021-11-01T14:33:49Z 2021-11-01T14:33:49Z 2021-06-17 2021-07-30T03:17:25Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136857 en https://doi.org/10.1557/s43577-021-00122-3 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The Author(s), under exclusive licence to The Author(s), under exclusive License to the Materials Research Society application/pdf Springer International Publishing Springer International Publishing |
| spellingShingle | Raman, Ritu Engineered neuromuscular actuators for medicine, meat, and machines |
| title | Engineered neuromuscular actuators for medicine, meat, and machines |
| title_full | Engineered neuromuscular actuators for medicine, meat, and machines |
| title_fullStr | Engineered neuromuscular actuators for medicine, meat, and machines |
| title_full_unstemmed | Engineered neuromuscular actuators for medicine, meat, and machines |
| title_short | Engineered neuromuscular actuators for medicine, meat, and machines |
| title_sort | engineered neuromuscular actuators for medicine meat and machines |
| url | https://hdl.handle.net/1721.1/136857 |
| work_keys_str_mv | AT ramanritu engineeredneuromuscularactuatorsformedicinemeatandmachines |