Nucleic acid delivery and nanoparticle design for COVID vaccines

Abstract Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems. The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune levels of specific protein expression, achieving downregulation through short interfering...

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Main Authors: Andresen, Jason L., Fenton, Owen S.
Format: Article
Language:English
Published: Springer International Publishing 2021
Online Access:https://hdl.handle.net/1721.1/137053
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author Andresen, Jason L.
Fenton, Owen S.
author_facet Andresen, Jason L.
Fenton, Owen S.
author_sort Andresen, Jason L.
collection MIT
description Abstract Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems. The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune levels of specific protein expression, achieving downregulation through short interfering RNA (siRNA) or upregulation by messenger RNA (mRNA) administration. Recent advances in the development of delivery vehicles, including nonviral nanoparticles are crucial to overcome the innate barriers to nucleic acid delivery. Toward this end, current clinical approaches have utilized mRNA and lipid nanoparticles (LNPs) to address the COVID-19 pandemic through novel vaccine strategies, producing efficacious vaccines within one year of sequencing the SARS-CoV-2 genome. Here, we review fundamental concepts required to achieve successful nucleic acid delivery, including the design of LNP systems optimized for mRNA vaccine applications. Graphic abstract
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spelling mit-1721.1/1370532021-11-03T03:36:13Z Nucleic acid delivery and nanoparticle design for COVID vaccines Andresen, Jason L. Fenton, Owen S. Abstract Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems. The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune levels of specific protein expression, achieving downregulation through short interfering RNA (siRNA) or upregulation by messenger RNA (mRNA) administration. Recent advances in the development of delivery vehicles, including nonviral nanoparticles are crucial to overcome the innate barriers to nucleic acid delivery. Toward this end, current clinical approaches have utilized mRNA and lipid nanoparticles (LNPs) to address the COVID-19 pandemic through novel vaccine strategies, producing efficacious vaccines within one year of sequencing the SARS-CoV-2 genome. Here, we review fundamental concepts required to achieve successful nucleic acid delivery, including the design of LNP systems optimized for mRNA vaccine applications. Graphic abstract 2021-11-02T11:33:20Z 2021-11-02T11:33:20Z 2021-09-14 2021-11-02T04:19:30Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/137053 Andresen, Jason L. and Fenton, Owen S. 2021. "Nucleic acid delivery and nanoparticle design for COVID vaccines." en https://doi.org/10.1557/s43577-021-00169-2 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The Author(s), under exclusive licence to The Author(s), under exclusive License to the Materials Research Society application/pdf Springer International Publishing Springer International Publishing
spellingShingle Andresen, Jason L.
Fenton, Owen S.
Nucleic acid delivery and nanoparticle design for COVID vaccines
title Nucleic acid delivery and nanoparticle design for COVID vaccines
title_full Nucleic acid delivery and nanoparticle design for COVID vaccines
title_fullStr Nucleic acid delivery and nanoparticle design for COVID vaccines
title_full_unstemmed Nucleic acid delivery and nanoparticle design for COVID vaccines
title_short Nucleic acid delivery and nanoparticle design for COVID vaccines
title_sort nucleic acid delivery and nanoparticle design for covid vaccines
url https://hdl.handle.net/1721.1/137053
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