Bioelectrochemical platforms to study and detect emerging pathogens
Abstract The ongoing SARS-CoV-2 pandemic has emphasized the importance of technologies to rapidly detect emerging pathogens and understand their interactions with hosts. Platforms based on the combination of biological recognition and electrochemical signal transduction, generally ter...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer International Publishing
2021
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| Online Access: | https://hdl.handle.net/1721.1/137054 |
| _version_ | 1826217976883314688 |
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| author | Machado, Mary C. Zamani, Marjon Daniel, Susan Furst, Ariel L. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Machado, Mary C. Zamani, Marjon Daniel, Susan Furst, Ariel L. |
| author_sort | Machado, Mary C. |
| collection | MIT |
| description | Abstract
The ongoing SARS-CoV-2 pandemic has emphasized the importance of technologies to rapidly detect emerging pathogens and understand their interactions with hosts. Platforms based on the combination of biological recognition and electrochemical signal transduction, generally termed bioelectrochemical platforms, offer unique opportunities to both sense and study pathogens. Improved bio-based materials have enabled enhanced control over the biotic–abiotic interface in these systems. These improvements have generated platforms with the capability to elucidate biological function rather than simply detect targets. This advantage is a key feature of recent bioelectrochemical platforms applied to infectious disease. Here, we describe developments in materials for bioelectrochemical platforms to study and detect emerging pathogens. The incorporation of host membrane material into electrochemical devices has provided unparalleled insights into the interaction between viruses and host cells, and new capture methods have enabled the specific detection of bacterial pathogens, such as those that cause secondary infections with SARS-CoV-2. As these devices continue to improve through the merging of hi-tech materials and biomaterials, the scalability and commercial viability of these devices will similarly improve.
Graphic Abstract |
| first_indexed | 2024-09-23T17:12:11Z |
| format | Article |
| id | mit-1721.1/137054 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:12:11Z |
| publishDate | 2021 |
| publisher | Springer International Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1370542023-02-09T16:20:40Z Bioelectrochemical platforms to study and detect emerging pathogens Machado, Mary C. Zamani, Marjon Daniel, Susan Furst, Ariel L. Massachusetts Institute of Technology. Department of Chemical Engineering Abstract The ongoing SARS-CoV-2 pandemic has emphasized the importance of technologies to rapidly detect emerging pathogens and understand their interactions with hosts. Platforms based on the combination of biological recognition and electrochemical signal transduction, generally termed bioelectrochemical platforms, offer unique opportunities to both sense and study pathogens. Improved bio-based materials have enabled enhanced control over the biotic–abiotic interface in these systems. These improvements have generated platforms with the capability to elucidate biological function rather than simply detect targets. This advantage is a key feature of recent bioelectrochemical platforms applied to infectious disease. Here, we describe developments in materials for bioelectrochemical platforms to study and detect emerging pathogens. The incorporation of host membrane material into electrochemical devices has provided unparalleled insights into the interaction between viruses and host cells, and new capture methods have enabled the specific detection of bacterial pathogens, such as those that cause secondary infections with SARS-CoV-2. As these devices continue to improve through the merging of hi-tech materials and biomaterials, the scalability and commercial viability of these devices will similarly improve. Graphic Abstract 2021-11-02T11:34:06Z 2021-11-02T11:34:06Z 2021-08-31 2021-11-02T04:19:27Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/137054 Machado, Mary C., Zamani, Marjon, Daniel, Susan and Furst, Ariel L. 2021. "Bioelectrochemical platforms to study and detect emerging pathogens." en https://doi.org/10.1557/s43577-021-00172-7 Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ The Author(s), under exclusive licence to The Author(s), under exclusive License to the Materials Research Society application/pdf Springer International Publishing Springer International Publishing |
| spellingShingle | Machado, Mary C. Zamani, Marjon Daniel, Susan Furst, Ariel L. Bioelectrochemical platforms to study and detect emerging pathogens |
| title | Bioelectrochemical platforms to study and detect emerging pathogens |
| title_full | Bioelectrochemical platforms to study and detect emerging pathogens |
| title_fullStr | Bioelectrochemical platforms to study and detect emerging pathogens |
| title_full_unstemmed | Bioelectrochemical platforms to study and detect emerging pathogens |
| title_short | Bioelectrochemical platforms to study and detect emerging pathogens |
| title_sort | bioelectrochemical platforms to study and detect emerging pathogens |
| url | https://hdl.handle.net/1721.1/137054 |
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