Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Abstract Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD. Lewy pathology is found in the majority of individuals...

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Bibliographic Details
Main Authors: Brzozowski, Charlotte F., Hijaz, Baraa A., Singh, Vijay, Gcwensa, Nolwazi Z., Kelly, Kaela, Boyden, Edward S., West, Andrew B., Sarkar, Deblina, Volpicelli-Daley, Laura A.
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: BioMed Central 2021
Online Access:https://hdl.handle.net/1721.1/138128

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