Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time
© 2020 Elsevier Inc. We propose a new paradigm for dense functional imaging of brain activity to surmount the limitations of present methodologies. We term this approach “integrated neurophotonics”; it combines recent advances in microchip-based integrated photonic and electronic circuitry with thos...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/138171 |
| _version_ | 1811088752367370240 |
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| author | Moreaux, Laurent C Yatsenko, Dimitri Sacher, Wesley D Choi, Jaebin Lee, Changhyuk Kubat, Nicole J Cotton, R James Boyden, Edward S Lin, Michael Z Tian, Lin Tolias, Andreas S Poon, Joyce KS Shepard, Kenneth L Roukes, Michael L |
| author2 | Howard Hughes Medical Institute |
| author_facet | Howard Hughes Medical Institute Moreaux, Laurent C Yatsenko, Dimitri Sacher, Wesley D Choi, Jaebin Lee, Changhyuk Kubat, Nicole J Cotton, R James Boyden, Edward S Lin, Michael Z Tian, Lin Tolias, Andreas S Poon, Joyce KS Shepard, Kenneth L Roukes, Michael L |
| author_sort | Moreaux, Laurent C |
| collection | MIT |
| description | © 2020 Elsevier Inc. We propose a new paradigm for dense functional imaging of brain activity to surmount the limitations of present methodologies. We term this approach “integrated neurophotonics”; it combines recent advances in microchip-based integrated photonic and electronic circuitry with those from optogenetics. This approach has the potential to enable lens-less functional imaging from within the brain itself to achieve dense, large-scale stimulation and recording of brain activity with cellular resolution at arbitrary depths. We perform a computational study of several prototype 3D architectures for implantable probe-array modules that are designed to provide fast and dense single-cell resolution (e.g., within a 1-mm3 volume of mouse cortex comprising ∼100,000 neurons). We describe progress toward realizing integrated neurophotonic imaging modules, which can be produced en masse with current semiconductor foundry protocols for chip manufacturing. Implantation of multiple modules can cover extended brain regions. Moreaux et al. describe a new paradigm for dense functional imaging of brain activity that surmounts limitations of present methodologies. It enables functional imaging from within the brain, permitting dense, large-scale brain circuit interrogation with cellular resolution at arbitrary depths. |
| first_indexed | 2024-09-23T14:06:56Z |
| format | Article |
| id | mit-1721.1/138171 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:06:56Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1381712023-12-07T14:39:23Z Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time Moreaux, Laurent C Yatsenko, Dimitri Sacher, Wesley D Choi, Jaebin Lee, Changhyuk Kubat, Nicole J Cotton, R James Boyden, Edward S Lin, Michael Z Tian, Lin Tolias, Andreas S Poon, Joyce KS Shepard, Kenneth L Roukes, Michael L Howard Hughes Medical Institute McGovern Institute for Brain Research at MIT Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Program in Media Arts and Sciences (Massachusetts Institute of Technology) Massachusetts Institute of Technology. Department of Biological Engineering © 2020 Elsevier Inc. We propose a new paradigm for dense functional imaging of brain activity to surmount the limitations of present methodologies. We term this approach “integrated neurophotonics”; it combines recent advances in microchip-based integrated photonic and electronic circuitry with those from optogenetics. This approach has the potential to enable lens-less functional imaging from within the brain itself to achieve dense, large-scale stimulation and recording of brain activity with cellular resolution at arbitrary depths. We perform a computational study of several prototype 3D architectures for implantable probe-array modules that are designed to provide fast and dense single-cell resolution (e.g., within a 1-mm3 volume of mouse cortex comprising ∼100,000 neurons). We describe progress toward realizing integrated neurophotonic imaging modules, which can be produced en masse with current semiconductor foundry protocols for chip manufacturing. Implantation of multiple modules can cover extended brain regions. Moreaux et al. describe a new paradigm for dense functional imaging of brain activity that surmounts limitations of present methodologies. It enables functional imaging from within the brain, permitting dense, large-scale brain circuit interrogation with cellular resolution at arbitrary depths. 2021-11-19T19:48:01Z 2021-11-19T19:48:01Z 2020 2021-11-19T19:43:44Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138171 Moreaux, Laurent C, Yatsenko, Dimitri, Sacher, Wesley D, Choi, Jaebin, Lee, Changhyuk et al. 2020. "Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time." Neuron, 108 (1). en 10.1016/J.NEURON.2020.09.043 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Moreaux, Laurent C Yatsenko, Dimitri Sacher, Wesley D Choi, Jaebin Lee, Changhyuk Kubat, Nicole J Cotton, R James Boyden, Edward S Lin, Michael Z Tian, Lin Tolias, Andreas S Poon, Joyce KS Shepard, Kenneth L Roukes, Michael L Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title | Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title_full | Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title_fullStr | Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title_full_unstemmed | Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title_short | Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity—at Depth and in Real Time |
| title_sort | integrated neurophotonics toward dense volumetric interrogation of brain circuit activity at depth and in real time |
| url | https://hdl.handle.net/1721.1/138171 |
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