Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model
© 2020 Elsevier Inc. Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjecti...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
|
| Online Access: | https://hdl.handle.net/1721.1/138257 |
| _version_ | 1826208208209838080 |
|---|---|
| author | Friedman, Alexander Hueske, Emily Drammis, Sabrina M Toro Arana, Sebastian E Nelson, Erik D Carter, Cody W Delcasso, Sebastien Rodriguez, Raimundo X Lutwak, Hope DiMarco, Kaden S Zhang, Qingyang Rakocevic, Lara I Hu, Dan Xiong, Joshua K Zhao, Jiajia Gibb, Leif G Yoshida, Tomoko Siciliano, Cody A Diefenbach, Thomas J Ramakrishnan, Charu Deisseroth, Karl Graybiel, Ann M |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Friedman, Alexander Hueske, Emily Drammis, Sabrina M Toro Arana, Sebastian E Nelson, Erik D Carter, Cody W Delcasso, Sebastien Rodriguez, Raimundo X Lutwak, Hope DiMarco, Kaden S Zhang, Qingyang Rakocevic, Lara I Hu, Dan Xiong, Joshua K Zhao, Jiajia Gibb, Leif G Yoshida, Tomoko Siciliano, Cody A Diefenbach, Thomas J Ramakrishnan, Charu Deisseroth, Karl Graybiel, Ann M |
| author_sort | Friedman, Alexander |
| collection | MIT |
| description | © 2020 Elsevier Inc. Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders. |
| first_indexed | 2024-09-23T14:02:14Z |
| format | Article |
| id | mit-1721.1/138257 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:02:14Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1382572024-01-02T20:46:18Z Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model Friedman, Alexander Hueske, Emily Drammis, Sabrina M Toro Arana, Sebastian E Nelson, Erik D Carter, Cody W Delcasso, Sebastien Rodriguez, Raimundo X Lutwak, Hope DiMarco, Kaden S Zhang, Qingyang Rakocevic, Lara I Hu, Dan Xiong, Joshua K Zhao, Jiajia Gibb, Leif G Yoshida, Tomoko Siciliano, Cody A Diefenbach, Thomas J Ramakrishnan, Charu Deisseroth, Karl Graybiel, Ann M Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Ragon Institute of MGH, MIT and Harvard © 2020 Elsevier Inc. Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders. 2021-11-30T19:14:39Z 2021-11-30T19:14:39Z 2020 2021-11-30T19:06:56Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138257 Friedman, Alexander, Hueske, Emily, Drammis, Sabrina M, Toro Arana, Sebastian E, Nelson, Erik D et al. 2020. "Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model." Cell, 183 (4). en 10.1016/J.CELL.2020.09.060 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Friedman, Alexander Hueske, Emily Drammis, Sabrina M Toro Arana, Sebastian E Nelson, Erik D Carter, Cody W Delcasso, Sebastien Rodriguez, Raimundo X Lutwak, Hope DiMarco, Kaden S Zhang, Qingyang Rakocevic, Lara I Hu, Dan Xiong, Joshua K Zhao, Jiajia Gibb, Leif G Yoshida, Tomoko Siciliano, Cody A Diefenbach, Thomas J Ramakrishnan, Charu Deisseroth, Karl Graybiel, Ann M Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title | Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title_full | Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title_fullStr | Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title_full_unstemmed | Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title_short | Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model |
| title_sort | striosomes mediate value based learning vulnerable in age and a huntington s disease model |
| url | https://hdl.handle.net/1721.1/138257 |
| work_keys_str_mv | AT friedmanalexander striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT hueskeemily striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT drammissabrinam striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT toroaranasebastiane striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT nelsonerikd striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT cartercodyw striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT delcassosebastien striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT rodriguezraimundox striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT lutwakhope striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT dimarcokadens striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT zhangqingyang striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT rakoceviclarai striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT hudan striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT xiongjoshuak striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT zhaojiajia striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT gibbleifg striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT yoshidatomoko striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT sicilianocodya striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT diefenbachthomasj striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT ramakrishnancharu striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT deisserothkarl striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel AT graybielannm striosomesmediatevaluebasedlearningvulnerableinageandahuntingtonsdiseasemodel |