CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and levodopa-induced dyskinesia in Parkinson'...

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Bibliographic Details
Main Authors: Crittenden, Jill R, Zhai, Shenyu, Sauvage, Magdalena, Kitsukawa, Takashi, Burguière, Eric, Thomsen, Morgane, Zhang, Hui, Costa, Cinzia, Martella, Giuseppina, Ghiglieri, Veronica, Picconi, Barbara, Pescatore, Karen A, Unterwald, Ellen M, Jackson, Walker S, Housman, David E, Caine, S Barak, Sulzer, David, Calabresi, Paolo, Smith, Anne C, Surmeier, D James, Graybiel, Ann M
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/138259

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