Thalamic circuits for independent control of prefrontal signal and noise
<jats:title>Abstract</jats:title><jats:p>Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for cognition. Studies in humans indicate that these interactions may resolve uncertainty in decision-making<jats:sup>1</jats:sup>, but the prec...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
|
| Online Access: | https://hdl.handle.net/1721.1/138260 |
| _version_ | 1811068684301500416 |
|---|---|
| author | Mukherjee, Arghya Lam, Norman H Wimmer, Ralf D Halassa, Michael M |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Mukherjee, Arghya Lam, Norman H Wimmer, Ralf D Halassa, Michael M |
| author_sort | Mukherjee, Arghya |
| collection | MIT |
| description | <jats:title>Abstract</jats:title><jats:p>Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for cognition. Studies in humans indicate that these interactions may resolve uncertainty in decision-making<jats:sup>1</jats:sup>, but the precise mechanisms are unknown. Here we identify two distinct mediodorsal projections to the prefrontal cortex that have complementary mechanistic roles in decision-making under uncertainty. Specifically, we found that a dopamine receptor (D2)-expressing projection amplifies prefrontal signals when task inputs are sparse and a kainate receptor (GRIK4) expressing-projection suppresses prefrontal noise when task inputs are dense but conflicting. Collectively, our data suggest that there are distinct brain mechanisms for handling uncertainty due to low signals versus uncertainty due to high noise, and provide a mechanistic entry point for correcting decision-making abnormalities in disorders that have a prominent prefrontal component<jats:sup>2–6</jats:sup>.</jats:p> |
| first_indexed | 2024-09-23T07:59:34Z |
| format | Article |
| id | mit-1721.1/138260 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T07:59:34Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1382602023-08-07T18:03:36Z Thalamic circuits for independent control of prefrontal signal and noise Mukherjee, Arghya Lam, Norman H Wimmer, Ralf D Halassa, Michael M McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:title>Abstract</jats:title><jats:p>Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for cognition. Studies in humans indicate that these interactions may resolve uncertainty in decision-making<jats:sup>1</jats:sup>, but the precise mechanisms are unknown. Here we identify two distinct mediodorsal projections to the prefrontal cortex that have complementary mechanistic roles in decision-making under uncertainty. Specifically, we found that a dopamine receptor (D2)-expressing projection amplifies prefrontal signals when task inputs are sparse and a kainate receptor (GRIK4) expressing-projection suppresses prefrontal noise when task inputs are dense but conflicting. Collectively, our data suggest that there are distinct brain mechanisms for handling uncertainty due to low signals versus uncertainty due to high noise, and provide a mechanistic entry point for correcting decision-making abnormalities in disorders that have a prominent prefrontal component<jats:sup>2–6</jats:sup>.</jats:p> 2021-11-30T19:42:21Z 2021-11-30T19:42:21Z 2021-10-06 2021-11-30T19:39:37Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138260 Mukherjee, Arghya, Lam, Norman H, Wimmer, Ralf D and Halassa, Michael M. 2021. "Thalamic circuits for independent control of prefrontal signal and noise." Nature. en 10.1038/s41586-021-04056-3 Nature Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Mukherjee, Arghya Lam, Norman H Wimmer, Ralf D Halassa, Michael M Thalamic circuits for independent control of prefrontal signal and noise |
| title | Thalamic circuits for independent control of prefrontal signal and noise |
| title_full | Thalamic circuits for independent control of prefrontal signal and noise |
| title_fullStr | Thalamic circuits for independent control of prefrontal signal and noise |
| title_full_unstemmed | Thalamic circuits for independent control of prefrontal signal and noise |
| title_short | Thalamic circuits for independent control of prefrontal signal and noise |
| title_sort | thalamic circuits for independent control of prefrontal signal and noise |
| url | https://hdl.handle.net/1721.1/138260 |
| work_keys_str_mv | AT mukherjeearghya thalamiccircuitsforindependentcontrolofprefrontalsignalandnoise AT lamnormanh thalamiccircuitsforindependentcontrolofprefrontalsignalandnoise AT wimmerralfd thalamiccircuitsforindependentcontrolofprefrontalsignalandnoise AT halassamichaelm thalamiccircuitsforindependentcontrolofprefrontalsignalandnoise |