An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
© 2020 IOP Publishing Ltd. Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. Objective. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrod...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2021
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| Online Access: | https://hdl.handle.net/1721.1/138265.2 |
| _version_ | 1811074838223126528 |
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| author | Voigts, Jakob Newman, Jonathan P. Wilson, Matthew A. Harnett, Mark T. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Voigts, Jakob Newman, Jonathan P. Wilson, Matthew A. Harnett, Mark T. |
| author_sort | Voigts, Jakob |
| collection | MIT |
| description | © 2020 IOP Publishing Ltd. Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. Objective. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. Approach. Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. Main results. The design presents an improvement over existing implants in terms of robustness, weight, and ease of use. We describe two variants: a 16 tetrode implant weighing ∼2 g for mice, bats, tree shrews and similar animals, and a 64 tetrode implant weighing ∼16 g for rats and similar animals. These designs were co-developed and optimized alongside a new class of drive-mounted feature-rich amplifier boards with ultra-thin radio-frequency tethers, as described in an upcoming paper (Newman, Zhang et al in prep). Significance. This design significantly improves the data yield of chronic electrophysiology experiments. |
| first_indexed | 2024-09-23T09:56:14Z |
| format | Article |
| id | mit-1721.1/138265.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:56:14Z |
| publishDate | 2021 |
| publisher | IOP Publishing |
| record_format | dspace |
| spelling | mit-1721.1/138265.22021-12-01T15:59:07Z An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals Voigts, Jakob Newman, Jonathan P. Wilson, Matthew A. Harnett, Mark T. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Picower Institute for Learning and Memory © 2020 IOP Publishing Ltd. Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. Objective. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. Approach. Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. Main results. The design presents an improvement over existing implants in terms of robustness, weight, and ease of use. We describe two variants: a 16 tetrode implant weighing ∼2 g for mice, bats, tree shrews and similar animals, and a 64 tetrode implant weighing ∼16 g for rats and similar animals. These designs were co-developed and optimized alongside a new class of drive-mounted feature-rich amplifier boards with ultra-thin radio-frequency tethers, as described in an upcoming paper (Newman, Zhang et al in prep). Significance. This design significantly improves the data yield of chronic electrophysiology experiments. NIH (Grants R01NS106-031 and R21NS103-098) Simons Center for the Social Brain at MIT (Fellowship R21-EY028-381) NSF (Award CCF-1231216) NIH (Awards 1F32MH107-086-01,TR01-GM104-948, R01-MH092-638) 2021-12-01T15:59:06Z 2021-12-01T15:24:20Z 2021-12-01T15:59:06Z 2020 2021-12-01T15:21:33Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138265.2 Voigts, Jakob, Newman, Jonathan P, Wilson, Matthew A and Harnett, Mark T. 2020. "An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals." Journal of Neural Engineering, 17 (2). en 10.1088/1741-2552/AB77F9 Journal of Neural Engineering Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/octet-stream IOP Publishing IOP Publishing |
| spellingShingle | Voigts, Jakob Newman, Jonathan P. Wilson, Matthew A. Harnett, Mark T. An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title | An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title_full | An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title_fullStr | An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title_full_unstemmed | An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title_short | An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| title_sort | easy to assemble robust and lightweight drive implant for chronic tetrode recordings in freely moving animals |
| url | https://hdl.handle.net/1721.1/138265.2 |
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