Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation
© 2019 Elsevier Inc. Active amplification of organized synaptic inputs in dendrites can endow individual neurons with the ability to perform complex computations. However, whether dendrites in behaving animals perform independent local computations is not known. Such activity may be particularly imp...
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| 其他作者: | |
| 格式: | 文件 |
| 语言: | English |
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Elsevier BV
2021
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| 在线阅读: | https://hdl.handle.net/1721.1/138266 |
| _version_ | 1826205238779969536 |
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| author | Voigts, Jakob Harnett, Mark T |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Voigts, Jakob Harnett, Mark T |
| author_sort | Voigts, Jakob |
| collection | MIT |
| description | © 2019 Elsevier Inc. Active amplification of organized synaptic inputs in dendrites can endow individual neurons with the ability to perform complex computations. However, whether dendrites in behaving animals perform independent local computations is not known. Such activity may be particularly important for complex behavior, where neurons integrate multiple streams of information. Head-restrained imaging has yielded important insights into cellular and circuit function, but this approach limits behavior and the underlying computations. We describe a method for full-featured 2-photon imaging in awake mice during free locomotion with volitional head rotation. We examine head direction and position encoding in simultaneously imaged apical tuft dendrites and their respective cell bodies in retrosplenial cortex, an area that encodes multi-modal navigational information. Activity in dendrites was not determined solely by somatic activity but reflected distinct navigational variables, fulfilling the requirements for dendritic computation. Our approach provides a foundation for studying sub-cellular processes during complex behaviors. |
| first_indexed | 2024-09-23T13:09:52Z |
| format | Article |
| id | mit-1721.1/138266 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:09:52Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1382662023-06-22T13:30:09Z Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation Voigts, Jakob Harnett, Mark T Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT © 2019 Elsevier Inc. Active amplification of organized synaptic inputs in dendrites can endow individual neurons with the ability to perform complex computations. However, whether dendrites in behaving animals perform independent local computations is not known. Such activity may be particularly important for complex behavior, where neurons integrate multiple streams of information. Head-restrained imaging has yielded important insights into cellular and circuit function, but this approach limits behavior and the underlying computations. We describe a method for full-featured 2-photon imaging in awake mice during free locomotion with volitional head rotation. We examine head direction and position encoding in simultaneously imaged apical tuft dendrites and their respective cell bodies in retrosplenial cortex, an area that encodes multi-modal navigational information. Activity in dendrites was not determined solely by somatic activity but reflected distinct navigational variables, fulfilling the requirements for dendritic computation. Our approach provides a foundation for studying sub-cellular processes during complex behaviors. 2021-12-01T15:27:33Z 2021-12-01T15:27:33Z 2020 2021-12-01T15:25:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138266 Voigts, Jakob and Harnett, Mark T. 2020. "Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation." Neuron, 105 (2). en 10.1016/J.NEURON.2019.10.016 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Voigts, Jakob Harnett, Mark T Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title | Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title_full | Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title_fullStr | Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title_full_unstemmed | Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title_short | Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation |
| title_sort | somatic and dendritic encoding of spatial variables in retrosplenial cortex differs during 2d navigation |
| url | https://hdl.handle.net/1721.1/138266 |
| work_keys_str_mv | AT voigtsjakob somaticanddendriticencodingofspatialvariablesinretrosplenialcortexdiffersduring2dnavigation AT harnettmarkt somaticanddendriticencodingofspatialvariablesinretrosplenialcortexdiffersduring2dnavigation |