A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex
The theory of predictive processing posits that the brain computes expectations to process information predictively. Empirical evidence in support of this theory, however, is scarce and largely limited to sensory areas. Here, we report a precise and adaptive mechanism in the frontal cortex of non-hu...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/138271.2 |
| _version_ | 1810973294649671680 |
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| author | Meirhaeghe, Nicolas Sohn, Hansem Jazayeri, Mehrdad |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Meirhaeghe, Nicolas Sohn, Hansem Jazayeri, Mehrdad |
| author_sort | Meirhaeghe, Nicolas |
| collection | MIT |
| description | The theory of predictive processing posits that the brain computes expectations to process information predictively. Empirical evidence in support of this theory, however, is scarce and largely limited to sensory areas. Here, we report a precise and adaptive mechanism in the frontal cortex of non-human primates consistent with predictive processing of temporal events. We found that the speed of neural dynamics is precisely adjusted according to the average time of an expected stimulus. This speed adjustment, in turn, enables neurons to encode stimuli in terms of deviations from expectation. This lawful relationship was evident across multiple experiments and held true during learning: when temporal statistics underwent covert changes, neural responses underwent predictable changes that reflected the new mean. Together, these results highlight a precise mathematical relationship between temporal statistics in the environment and neural activity in the frontal cortex that may serve as a mechanism for predictive temporal processing. |
| first_indexed | 2024-09-23T08:05:18Z |
| format | Article |
| id | mit-1721.1/138271.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:05:18Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/138271.22021-12-01T16:41:25Z A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex Meirhaeghe, Nicolas Sohn, Hansem Jazayeri, Mehrdad McGovern Institute for Brain Research at MIT Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences The theory of predictive processing posits that the brain computes expectations to process information predictively. Empirical evidence in support of this theory, however, is scarce and largely limited to sensory areas. Here, we report a precise and adaptive mechanism in the frontal cortex of non-human primates consistent with predictive processing of temporal events. We found that the speed of neural dynamics is precisely adjusted according to the average time of an expected stimulus. This speed adjustment, in turn, enables neurons to encode stimuli in terms of deviations from expectation. This lawful relationship was evident across multiple experiments and held true during learning: when temporal statistics underwent covert changes, neural responses underwent predictable changes that reflected the new mean. Together, these results highlight a precise mathematical relationship between temporal statistics in the environment and neural activity in the frontal cortex that may serve as a mechanism for predictive temporal processing. 2021-12-01T16:41:24Z 2021-12-01T16:25:22Z 2021-12-01T16:41:24Z 2021-09 2021-12-01T16:23:25Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138271.2 Meirhaeghe, Nicolas, Sohn, Hansem and Jazayeri, Mehrdad. 2021. "A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex." Neuron, 109 (18). en 10.1016/j.neuron.2021.08.025 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/octet-stream Elsevier BV bioRxiv |
| spellingShingle | Meirhaeghe, Nicolas Sohn, Hansem Jazayeri, Mehrdad A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title | A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title_full | A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title_fullStr | A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title_full_unstemmed | A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title_short | A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| title_sort | precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex |
| url | https://hdl.handle.net/1721.1/138271.2 |
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