Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer’s disease. We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefrontal...

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Bibliographic Details
Main Authors: Klein, Hans-Ulrich, McCabe, Cristin, Gjoneska, Elizabeta, Sullivan, Sarah E, Kaskow, Belinda J, Tang, Anna, Smith, Robert V, Xu, Jishu, Pfenning, Andreas R, Bernstein, Bradley E, Meissner, Alexander, Schneider, Julie A, Mostafavi, Sara, Tsai, Li-Huei, Young-Pearse, Tracy L, Bennett, David A, De Jager, Philip L
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:English
Published: Springer Nature 2021
Online Access:https://hdl.handle.net/1721.1/138336

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