Programmable Inhibition and Detection of RNA Viruses Using Cas13

Programmable Inhibition and Detection of RNA Viruses Using Cas13

© 2019 The Authors The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA). Here, we computationally identify thousands of potential Cas13 crRNA target sites in hundreds of ssRNA vi...

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Bibliographic Details
Main Authors: Freije, Catherine A, Myhrvold, Cameron, Boehm, Chloe K, Lin, Aaron E, Welch, Nicole L, Carter, Amber, Metsky, Hayden C, Luo, Cynthia Y, Abudayyeh, Omar O, Gootenberg, Jonathan S, Yozwiak, Nathan L, Zhang, Feng, Sabeti, Pardis C
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/138385

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