A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease
Copyright © 2020 The Authors, Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive decline, memory loss, and inability to perform everyday functions. Hallmark features of AD—including generation of amyloid plaques, neurofibrillary tangles, gliosis, and inflammation in the b...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/138397 |
| _version_ | 1826202689160085504 |
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| author | Cairns, Dana M Rouleau, Nicolas Parker, Rachael N Walsh, Katherine G Gehrke, Lee Kaplan, David L |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Cairns, Dana M Rouleau, Nicolas Parker, Rachael N Walsh, Katherine G Gehrke, Lee Kaplan, David L |
| author_sort | Cairns, Dana M |
| collection | MIT |
| description | Copyright © 2020 The Authors, Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive decline, memory loss, and inability to perform everyday functions. Hallmark features of AD—including generation of amyloid plaques, neurofibrillary tangles, gliosis, and inflammation in the brain—are well defined; however, the cause of the disease remains elusive. Growing evidence implicates pathogens in AD development, with herpes simplex virus type I (HSV-1) gaining increasing attention as a potential causative agent. Here, we describe a multidisciplinary approach to produce physiologically relevant human tissues to study AD using human-induced neural stem cells (hiNSCs) and HSV-1 infection in a 3D bioengineered brain model. We report a herpes-induced tissue model of AD that mimics human disease with multicellular amyloid plaque–like formations, gliosis, neuroinflammation, and decreased functionality, completely in the absence of any exogenous mediators of AD. This model will allow for future studies to identify potential downstream drug targets for treating this devastating disease. |
| first_indexed | 2024-09-23T12:14:28Z |
| format | Article |
| id | mit-1721.1/138397 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:14:28Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1383972024-03-19T13:57:16Z A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease Cairns, Dana M Rouleau, Nicolas Parker, Rachael N Walsh, Katherine G Gehrke, Lee Kaplan, David L Massachusetts Institute of Technology. Institute for Medical Engineering & Science Copyright © 2020 The Authors, Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive decline, memory loss, and inability to perform everyday functions. Hallmark features of AD—including generation of amyloid plaques, neurofibrillary tangles, gliosis, and inflammation in the brain—are well defined; however, the cause of the disease remains elusive. Growing evidence implicates pathogens in AD development, with herpes simplex virus type I (HSV-1) gaining increasing attention as a potential causative agent. Here, we describe a multidisciplinary approach to produce physiologically relevant human tissues to study AD using human-induced neural stem cells (hiNSCs) and HSV-1 infection in a 3D bioengineered brain model. We report a herpes-induced tissue model of AD that mimics human disease with multicellular amyloid plaque–like formations, gliosis, neuroinflammation, and decreased functionality, completely in the absence of any exogenous mediators of AD. This model will allow for future studies to identify potential downstream drug targets for treating this devastating disease. 2021-12-08T19:22:24Z 2021-12-08T19:22:24Z 2020 2021-12-08T19:19:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138397 Cairns, Dana M, Rouleau, Nicolas, Parker, Rachael N, Walsh, Katherine G, Gehrke, Lee et al. 2020. "A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease." Science Advances, 6 (19). en 10.1126/SCIADV.AAY8828 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Cairns, Dana M Rouleau, Nicolas Parker, Rachael N Walsh, Katherine G Gehrke, Lee Kaplan, David L A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title | A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title_full | A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title_fullStr | A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title_full_unstemmed | A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title_short | A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease |
| title_sort | 3d human brain like tissue model of herpes induced alzheimer s disease |
| url | https://hdl.handle.net/1721.1/138397 |
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