The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
Thesis: S.M. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, February, 2020
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2021
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| Online Access: | https://hdl.handle.net/1721.1/138518 |
| _version_ | 1826189487923789824 |
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| author | Templet, Sebastian (Sebastian Boyd) |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Templet, Sebastian (Sebastian Boyd) |
| author_sort | Templet, Sebastian (Sebastian Boyd) |
| collection | MIT |
| description | Thesis: S.M. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, February, 2020 |
| first_indexed | 2024-09-23T08:15:33Z |
| format | Thesis |
| id | mit-1721.1/138518 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T08:15:33Z |
| publishDate | 2021 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1385182021-12-18T03:47:43Z The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation Templet, Sebastian (Sebastian Boyd) Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brain and Cognitive Sciences. Thesis: S.M. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, February, 2020 Manuscript. Includes bibliographical references (pages 49-57). Activity-dependent changes in neuronal properties (neuronal plasticity) are critical for information processing and storage in the brain. It is well-established that protein synthesis is essential for both memory formation and the long-lasting changes in synaptic strength that accompany learning. However, it's still unclear when protein synthesis needs to occur relative to the experience to form durable memories, and the identities and roles of crucial proteins in these processes have not been elucidated. Neurogranin, a small protein that regulates calcium-dependent signaling, is poised to modulate both memory and synaptic plasticity. This thesis aims to provide insights into the molecular underpinnings mediating context memory formation in the hippocampus. By combining molecular, behavioral, pharmacological, and viral manipulations, we assessed the role of neurogranin in hippocampal memory formation and synaptic plasticity. We observed a rapid, activity-dependent upregulation of neurogranin mediated by FMRP. Neurogranin was found to be regulated by the adrenergic system, and our data suggested a role in the adrenergic-mediated enhancement in memory formation and a form of synaptic plasticity known as long-term potentiation. These findings strongly suggest that neurogranin plays an important role in regulating memory and synaptic plasticity. by Sebastian Templet. S.M. in Neuroscience S.M. in Neuroscience Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences 2021-12-17T17:04:34Z 2021-12-17T17:04:34Z 2020 2020 Thesis https://hdl.handle.net/1721.1/138518 1281177189 eng MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. http://dspace.mit.edu/handle/1721.1/7582 61 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Brain and Cognitive Sciences. Templet, Sebastian (Sebastian Boyd) The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title | The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title_full | The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title_fullStr | The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title_full_unstemmed | The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title_short | The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation |
| title_sort | role of neurogranin in modulating contextual memory and plasticity fmrp involvement and adrenergic dependent facilitation |
| topic | Brain and Cognitive Sciences. |
| url | https://hdl.handle.net/1721.1/138518 |
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