Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice
Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that <sup>56</sup>Fe irradiation, a significan...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | https://hdl.handle.net/1721.1/138779 |
| _version_ | 1826205258872782848 |
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| author | Schroeder, Maren K. Liu, Bin Hinshaw, Robert G. Park, Mi-Ae Wang, Shuyan Dubey, Shipra Liu, Grace Geyu Shi, Qiaoqiao Holton, Peter Reiser, Vladimir Jones, Paul A. Trigg, William Di Carli, Marcelo F. Caldarone, Barbara J. Williams, Jacqueline P. O’Banion, M. Kerry Lemere, Cynthia A. |
| author_facet | Schroeder, Maren K. Liu, Bin Hinshaw, Robert G. Park, Mi-Ae Wang, Shuyan Dubey, Shipra Liu, Grace Geyu Shi, Qiaoqiao Holton, Peter Reiser, Vladimir Jones, Paul A. Trigg, William Di Carli, Marcelo F. Caldarone, Barbara J. Williams, Jacqueline P. O’Banion, M. Kerry Lemere, Cynthia A. |
| author_sort | Schroeder, Maren K. |
| collection | MIT |
| description | Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that <sup>56</sup>Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer’s disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of <sup>56</sup>Fe irradiation is lacking. Here, we irradiated 4-month-old male and female, wild-type and Alzheimer’s-like APP/PS1 mice with 0, 0.10, or 0.50 Gy of <sup>56</sup>Fe ions (1GeV/u). Mice underwent microPET scans before and 7.5 months after irradiation, a battery of behavioral tests at 11 months of age and were sacrificed for pathological and biochemical analyses at 12 months of age. <sup>56</sup>Fe irradiation worsened amyloid-beta (Aβ) pathology, gliosis, neuroinflammation and spatial memory, but improved motor coordination, in male transgenic mice and worsened fear memory in wild-type males. Although sham-irradiated female APP/PS1 mice had more cerebral Aβ and gliosis than sham-irradiated male transgenics, female mice of both genotypes were relatively spared from radiation effects 8 months later. These results provide evidence for sex-specific, long-term CNS effects of space radiation. |
| first_indexed | 2024-09-23T13:09:52Z |
| format | Article |
| id | mit-1721.1/138779 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:09:52Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1387792022-01-04T03:18:18Z Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice Schroeder, Maren K. Liu, Bin Hinshaw, Robert G. Park, Mi-Ae Wang, Shuyan Dubey, Shipra Liu, Grace Geyu Shi, Qiaoqiao Holton, Peter Reiser, Vladimir Jones, Paul A. Trigg, William Di Carli, Marcelo F. Caldarone, Barbara J. Williams, Jacqueline P. O’Banion, M. Kerry Lemere, Cynthia A. Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that <sup>56</sup>Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer’s disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of <sup>56</sup>Fe irradiation is lacking. Here, we irradiated 4-month-old male and female, wild-type and Alzheimer’s-like APP/PS1 mice with 0, 0.10, or 0.50 Gy of <sup>56</sup>Fe ions (1GeV/u). Mice underwent microPET scans before and 7.5 months after irradiation, a battery of behavioral tests at 11 months of age and were sacrificed for pathological and biochemical analyses at 12 months of age. <sup>56</sup>Fe irradiation worsened amyloid-beta (Aβ) pathology, gliosis, neuroinflammation and spatial memory, but improved motor coordination, in male transgenic mice and worsened fear memory in wild-type males. Although sham-irradiated female APP/PS1 mice had more cerebral Aβ and gliosis than sham-irradiated male transgenics, female mice of both genotypes were relatively spared from radiation effects 8 months later. These results provide evidence for sex-specific, long-term CNS effects of space radiation. 2022-01-03T17:43:14Z 2022-01-03T17:43:14Z 2021-12-10 2021-12-23T15:06:43Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138779 International Journal of Molecular Sciences 22 (24): 13305 (2021) PUBLISHER_CC http://dx.doi.org/10.3390/ijms222413305 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Schroeder, Maren K. Liu, Bin Hinshaw, Robert G. Park, Mi-Ae Wang, Shuyan Dubey, Shipra Liu, Grace Geyu Shi, Qiaoqiao Holton, Peter Reiser, Vladimir Jones, Paul A. Trigg, William Di Carli, Marcelo F. Caldarone, Barbara J. Williams, Jacqueline P. O’Banion, M. Kerry Lemere, Cynthia A. Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title | Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title_full | Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title_fullStr | Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title_full_unstemmed | Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title_short | Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice |
| title_sort | long term sex and genotype specific effects of 56fe irradiation on wild type and appswe ps1de9 transgenic mice |
| url | https://hdl.handle.net/1721.1/138779 |
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