Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling are poorly understood. Here, we demonstrate that hepcidin is activated ectopically in CRC. Mice deficient in hepcidin specifically in the colon tumour epithelium, compared wit...

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Bibliographic Details
Main Authors:	Schwartz, Andrew J, Goyert, Joshua W, Solanki, Sumeet, Kerk, Samuel A, Chen, Brandon, Castillo, Cristina, Hsu, Peggy P, Do, Brian T, Singhal, Rashi, Dame, Michael K, Lee, Ho-Joon, Spence, Jason R, Lakhal-Littleton, Samira, Heiden, Matthew G Vander, Lyssiotis, Costas A, Xue, Xiang, Shah, Yatrik M
Format:	Article
Language:	English
Published:	Springer Science and Business Media LLC 2022
Online Access:	https://hdl.handle.net/1721.1/138808

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells by Schwartz, Andrew J., Goyert, Joshua W., Solanki, Sumeet, Kerk, Samuel A., Chen, Brandon, Castillo, Cristina, Hsu, Peggy P., Do, Brian T., Singhal, Rashi, Dame, Michael K., Lee, Ho-Joon, Spence, Jason R., Lakhal-Littleton, Samira, Vander Heiden, Matthew G., Lyssiotis, Costas A., Xue, Xiang, Shah, Yatrik M.

Published 2022

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Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

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