Clonal fitness inferred from time-series modelling of single-cell cancer genomes

Progress in defining genomic fitness landscapes in cancer, especially those defined by copy number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of polyclonal populations and temporal statistical models1-7. Here we generated 42,000 genomes from multi-year time-seri...

Full description

Bibliographic Details
Main Author: Boyden, Edward S.
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/138810
Search Result 1

Clonal fitness inferred from time-series modelling of single-cell cancer genomes by Salehi, Sohrab, Kabeer, Farhia, Ceglia, Nicholas, Andronescu, Mirela, Williams, Marc J., Campbell, Kieran R., Masud, Tehmina, Wang, Beixi, Biele, Justina, Brimhall, Jazmine, Gee, David, Lee, Hakwoo, Ting, Jerome, Zhang, Allen W., Tran, Hoa, O’Flanagan, Ciara, Dorri, Fatemeh, Rusk, Nicole, de Algara, Teresa Ruiz, Lee, So Ra, Cheng, Brian Yu Chieh, Eirew, Peter, Kono, Takako, Pham, Jenifer, Grewal, Diljot, Lai, Daniel, Moore, Richard, Mungall, Andrew J., Marra, Marco A., Hannon, Gregory J., Battistoni, Giorgia, Bressan, Dario, Cannell, Ian Gordon, Casbolt, Hannah, Fatemi, Atefeh, Jauset, Cristina, Kovačević, Tatjana, Mulvey, Claire M., Nugent, Fiona, Ribes, Marta Paez, Pearsall, Isabella, Qosaj, Fatime, Sawicka, Kirsty, Wild, Sophia A., Williams, Elena, Laks, Emma, Li, Yangguang, O’Flanagan, Ciara H., Smith, Austin, Ruiz, Teresa, Lai, Daniel, Roth, Andrew, Balasubramanian, Shankar, Lee, Maximillian, Bodenmiller, Bernd, Burger, Marcel, Kuett, Laura, Tietscher, Sandra, Windhager, Jonas, Boyden, Edward S., Alon, Shahar, Cui, Yi, Emenari, Amauche, Goodwin, Dan, Karagiannis, Emmanouil D., Sinha, Anubhav, Wassie, Asmamaw T., Caldas, Carlos, Bruna, Alejandra, Callari, Maurizio, Greenwood, Wendy, Lerda, Giulia, Eyal-Lubling, Yaniv, Rueda, Oscar M., Shea, Abigail, Harris, Owen, Becker, Robby, Grimaldi, Flaminia, Harris, Suvi, Vogl, Sara Lisa, Weselak, Joanna, Joyce, Johanna A., Watson, Spencer S., Vázquez-Garćıa, Ignacio, Tavaré, Simon, Dinh, Khanh N., Fisher, Eyal, Kunes, Russell, Walton, Nicholas A., Sa’d, Mohammad Al, Chornay, Nick, Dariush, Ali, González-Solares, Eduardo A., González-Fernández, Carlos, Yoldas, Aybüke Küpcü, Millar, Neil, Whitmarsh, Tristan, Zhuang, Xiaowei, Fan, Jean, Lee, Hsuan, Sepúlveda, Leonardo A., Xia, Chenglong, Zheng, Pu, McPherson, Andrew, Bouchard-Côté, Alexandre, Aparicio, Samuel, Shah, Sohrab P.

Published 2022
Get full text
Article