Minimally invasive electroceutical catheter for endoluminal defect sealing
Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy f...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2022
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| Online Access: | https://hdl.handle.net/1721.1/138896.2 |
| _version_ | 1811080203708923904 |
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| author | Singh, Manisha Varela, Claudia Elena Whyte, William Horvath, Markus A. Tan, Nigel CS Ong, Chee Bing Liang, Patric Schermerhorn, Marc L Roche, Ellen Steele, Terry WJ |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Singh, Manisha Varela, Claudia Elena Whyte, William Horvath, Markus A. Tan, Nigel CS Ong, Chee Bing Liang, Patric Schermerhorn, Marc L Roche, Ellen Steele, Terry WJ |
| author_sort | Singh, Manisha |
| collection | MIT |
| description | Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping. |
| first_indexed | 2024-09-23T11:27:30Z |
| format | Article |
| id | mit-1721.1/138896.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:27:30Z |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/138896.22022-01-12T18:52:54Z Minimally invasive electroceutical catheter for endoluminal defect sealing Singh, Manisha Varela, Claudia Elena Whyte, William Horvath, Markus A. Tan, Nigel CS Ong, Chee Bing Liang, Patric Schermerhorn, Marc L Roche, Ellen Steele, Terry WJ Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Mechanical Engineering Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping. 2022-01-12T18:52:53Z 2022-01-12T18:13:08Z 2022-01-12T18:52:53Z 2021 2022-01-12T18:04:20Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138896.2 Singh, Manisha, Varela, Claudia E, Whyte, William, Horvath, Markus A, Tan, Nigel CS et al. 2021. "Minimally invasive electroceutical catheter for endoluminal defect sealing." Science Advances, 7 (14). en 10.1126/SCIADV.ABF6855 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/octet-stream American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Singh, Manisha Varela, Claudia Elena Whyte, William Horvath, Markus A. Tan, Nigel CS Ong, Chee Bing Liang, Patric Schermerhorn, Marc L Roche, Ellen Steele, Terry WJ Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title | Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title_full | Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title_fullStr | Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title_full_unstemmed | Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title_short | Minimally invasive electroceutical catheter for endoluminal defect sealing |
| title_sort | minimally invasive electroceutical catheter for endoluminal defect sealing |
| url | https://hdl.handle.net/1721.1/138896.2 |
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