Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase
© 2020 Elsevier Ltd Cohen et al. demonstrate that carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) undergoes wider conformational changes than previously reported. Furthermore, these new conformations explain how the ACS subunit can interact with corrinoid Fe-S protein (CFeSP) in order t...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2022
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| Online Access: | https://hdl.handle.net/1721.1/139663 |
| _version_ | 1826215383721312256 |
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| author | Cohen, Steven E Brignole, Edward J Wittenborn, Elizabeth C Can, Mehmet Thompson, Samuel Ragsdale, Stephen W Drennan, Catherine L |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Cohen, Steven E Brignole, Edward J Wittenborn, Elizabeth C Can, Mehmet Thompson, Samuel Ragsdale, Stephen W Drennan, Catherine L |
| author_sort | Cohen, Steven E |
| collection | MIT |
| description | © 2020 Elsevier Ltd Cohen et al. demonstrate that carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) undergoes wider conformational changes than previously reported. Furthermore, these new conformations explain how the ACS subunit can interact with corrinoid Fe-S protein (CFeSP) in order to mediate a methyl transfer reaction instrumental for anaerobic carbon fixation. |
| first_indexed | 2024-09-23T16:26:38Z |
| format | Article |
| id | mit-1721.1/139663 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:26:38Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1396632023-02-14T20:36:46Z Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase Cohen, Steven E Brignole, Edward J Wittenborn, Elizabeth C Can, Mehmet Thompson, Samuel Ragsdale, Stephen W Drennan, Catherine L Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Biology Howard Hughes Medical Institute © 2020 Elsevier Ltd Cohen et al. demonstrate that carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) undergoes wider conformational changes than previously reported. Furthermore, these new conformations explain how the ACS subunit can interact with corrinoid Fe-S protein (CFeSP) in order to mediate a methyl transfer reaction instrumental for anaerobic carbon fixation. 2022-01-24T15:44:10Z 2022-01-24T15:44:10Z 2021 2022-01-24T15:38:40Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/139663 Cohen, Steven E, Brignole, Edward J, Wittenborn, Elizabeth C, Can, Mehmet, Thompson, Samuel et al. 2021. "Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase." Structure, 29 (1). en 10.1016/J.STR.2020.08.011 Structure Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Cohen, Steven E Brignole, Edward J Wittenborn, Elizabeth C Can, Mehmet Thompson, Samuel Ragsdale, Stephen W Drennan, Catherine L Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title | Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title_full | Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title_fullStr | Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title_full_unstemmed | Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title_short | Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase |
| title_sort | negative stain electron microscopy reveals dramatic structural rearrangements in ni fe s dependent carbon monoxide dehydrogenase acetyl coa synthase |
| url | https://hdl.handle.net/1721.1/139663 |
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