Hierarchical reasoning in the brain
When we interact in an uncertain environment, we continuously reason to disambiguate internal and external sources of uncertainty at multiple spatiotemporal scales to guide our goal-directed behavior. Understanding the neural mechanism of this reasoning behavior is essential for consequential applic...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/140134 |
| _version_ | 1826216857204424704 |
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| author | Sarafyazd, Morteza |
| author2 | Jazayeri, Mehrdad |
| author_facet | Jazayeri, Mehrdad Sarafyazd, Morteza |
| author_sort | Sarafyazd, Morteza |
| collection | MIT |
| description | When we interact in an uncertain environment, we continuously reason to disambiguate internal and external sources of uncertainty at multiple spatiotemporal scales to guide our goal-directed behavior. Understanding the neural mechanism of this reasoning behavior is essential for consequential applications in brain sciences. In this thesis, I address hierarchical reasoning at three levels of behavior, neural circuit, and computational models. First, I developed behavioral experiments to examine the reasoning behavior in dynamic environments with two hierarchical sources of uncertainty. The rational behavior necessitates evidence integration under multiple sources of uncertainty to update internal belief about the external environment. This behavioral study showed that human and non-human primates are able to reason accordingly by accumulating evidence to update their belief in a longer timescale. Second, I performed electrophysiology in the frontal cortex. The concurrent neural recordings revealed that brain regions in the frontal cortex carry signals related to reasoning behavior and performance monitoring. Third, to interpret the neural results, a probabilistic integrator model is implemented to address the key interpretable variables of the behavior. Finally, after observing the neural data, I aimed to explore neural hypotheses of the behavior through in-silico simulations of two neural-network models to perform the reasoning task. These simulations led to a better evaluation of proposed neural hypotheses relevant to key behavioral variables. |
| first_indexed | 2024-09-23T16:54:34Z |
| format | Thesis |
| id | mit-1721.1/140134 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:54:34Z |
| publishDate | 2022 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1401342022-02-08T03:01:48Z Hierarchical reasoning in the brain Sarafyazd, Morteza Jazayeri, Mehrdad Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences When we interact in an uncertain environment, we continuously reason to disambiguate internal and external sources of uncertainty at multiple spatiotemporal scales to guide our goal-directed behavior. Understanding the neural mechanism of this reasoning behavior is essential for consequential applications in brain sciences. In this thesis, I address hierarchical reasoning at three levels of behavior, neural circuit, and computational models. First, I developed behavioral experiments to examine the reasoning behavior in dynamic environments with two hierarchical sources of uncertainty. The rational behavior necessitates evidence integration under multiple sources of uncertainty to update internal belief about the external environment. This behavioral study showed that human and non-human primates are able to reason accordingly by accumulating evidence to update their belief in a longer timescale. Second, I performed electrophysiology in the frontal cortex. The concurrent neural recordings revealed that brain regions in the frontal cortex carry signals related to reasoning behavior and performance monitoring. Third, to interpret the neural results, a probabilistic integrator model is implemented to address the key interpretable variables of the behavior. Finally, after observing the neural data, I aimed to explore neural hypotheses of the behavior through in-silico simulations of two neural-network models to perform the reasoning task. These simulations led to a better evaluation of proposed neural hypotheses relevant to key behavioral variables. Ph.D. 2022-02-07T15:26:00Z 2022-02-07T15:26:00Z 2021-09 2021-11-12T14:45:00.372Z Thesis https://hdl.handle.net/1721.1/140134 In Copyright - Educational Use Permitted Copyright MIT http://rightsstatements.org/page/InC-EDU/1.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Sarafyazd, Morteza Hierarchical reasoning in the brain |
| title | Hierarchical reasoning in the brain |
| title_full | Hierarchical reasoning in the brain |
| title_fullStr | Hierarchical reasoning in the brain |
| title_full_unstemmed | Hierarchical reasoning in the brain |
| title_short | Hierarchical reasoning in the brain |
| title_sort | hierarchical reasoning in the brain |
| url | https://hdl.handle.net/1721.1/140134 |
| work_keys_str_mv | AT sarafyazdmorteza hierarchicalreasoninginthebrain |