Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design
Aerogels are ultralight porous materials whose matrix structure can be formed by interlinking 880 nm long M13 phage particles. In theory, changing the phage properties would alter the aerogel matrix, but attempting this using the current production system leads to heterogeneous lengths. A phagemid s...
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| Fformat: | Erthygl |
| Iaith: | English |
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Wiley
2022
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| Mynediad Ar-lein: | https://hdl.handle.net/1721.1/140277 |
| _version_ | 1826189592834867200 |
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| author | Cha, Tae‐Gon Tsedev, Uyanga Ransil, Alan Embree, Amanda Gordon, D. Benjamin Belcher, Angela M. Voigt, Christopher A. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Cha, Tae‐Gon Tsedev, Uyanga Ransil, Alan Embree, Amanda Gordon, D. Benjamin Belcher, Angela M. Voigt, Christopher A. |
| author_sort | Cha, Tae‐Gon |
| collection | MIT |
| description | Aerogels are ultralight porous materials whose matrix structure can be formed by interlinking 880 nm long M13 phage particles. In theory, changing the phage properties would alter the aerogel matrix, but attempting this using the current production system leads to heterogeneous lengths. A phagemid system that yields a narrow length distribution that can be tuned in 0.3 nm increments from 50 to 2500 nm is designed and, independently, the persistence length varies from 14 to 68 nm by mutating the coat protein. A robotic workflow that automates each step from DNA construction to aerogel synthesis is used to build 1200 aerogels. This is applied to compare Ni–MnOx cathodes built using different matrixes, revealing a pareto-optimal relationship between performance metrics. This work demonstrates the application of genetic engineering to create “tuning knobs” to sweep through material parameter space; in this case, toward creating a physically strong and high-capacity battery. |
| first_indexed | 2024-09-23T08:18:05Z |
| format | Article |
| id | mit-1721.1/140277 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:18:05Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1402772024-06-06T19:22:41Z Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design Cha, Tae‐Gon Tsedev, Uyanga Ransil, Alan Embree, Amanda Gordon, D. Benjamin Belcher, Angela M. Voigt, Christopher A. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Koch Institute for Integrative Cancer Research at MIT Aerogels are ultralight porous materials whose matrix structure can be formed by interlinking 880 nm long M13 phage particles. In theory, changing the phage properties would alter the aerogel matrix, but attempting this using the current production system leads to heterogeneous lengths. A phagemid system that yields a narrow length distribution that can be tuned in 0.3 nm increments from 50 to 2500 nm is designed and, independently, the persistence length varies from 14 to 68 nm by mutating the coat protein. A robotic workflow that automates each step from DNA construction to aerogel synthesis is used to build 1200 aerogels. This is applied to compare Ni–MnOx cathodes built using different matrixes, revealing a pareto-optimal relationship between performance metrics. This work demonstrates the application of genetic engineering to create “tuning knobs” to sweep through material parameter space; in this case, toward creating a physically strong and high-capacity battery. 2022-02-10T19:46:06Z 2022-02-10T19:46:06Z 2021-06-23 Article http://purl.org/eprint/type/JournalArticle 1616-301X 1616-3028 https://hdl.handle.net/1721.1/140277 Cha, T.-G., Tsedev, U., Ransil, A., Embree, A., Gordon, D. B., Belcher, A. M., Voigt, C. A., Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnOx Cathode Design. Adv. Funct. Mater. 2021, 31, 2010867 en http://dx.doi.org/10.1002/adfm.202010867 Advanced Functional Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Cha, Tae‐Gon Tsedev, Uyanga Ransil, Alan Embree, Amanda Gordon, D. Benjamin Belcher, Angela M. Voigt, Christopher A. Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title | Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title_full | Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title_fullStr | Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title_full_unstemmed | Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title_short | Genetic Control of Aerogel and Nanofoam Properties, Applied to Ni–MnO x Cathode Design |
| title_sort | genetic control of aerogel and nanofoam properties applied to ni mno x cathode design |
| url | https://hdl.handle.net/1721.1/140277 |
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