Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
>Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. T...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2022
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| Online Access: | https://hdl.handle.net/1721.1/140300 |
| _version_ | 1826192119108206592 |
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| author | Wei, He Wiśniowska, Agata Fan, Jingxuan Harvey, Peter Li, Yuanyuan Wu, Victoria Hansen, Eric C Zhang, Juanye Kaul, Michael G Frey, Abigail M Adam, Gerhard Frenkel, Anatoly I Bawendi, Moungi G Jasanoff, Alan |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Wei, He Wiśniowska, Agata Fan, Jingxuan Harvey, Peter Li, Yuanyuan Wu, Victoria Hansen, Eric C Zhang, Juanye Kaul, Michael G Frey, Abigail M Adam, Gerhard Frenkel, Anatoly I Bawendi, Moungi G Jasanoff, Alan |
| author_sort | Wei, He |
| collection | MIT |
| description | >Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in <jats:italic>T</jats:italic><jats:sub>1</jats:sub>-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood–brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials. |
| first_indexed | 2024-09-23T09:06:34Z |
| format | Article |
| id | mit-1721.1/140300 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:06:34Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1403002023-03-28T19:44:53Z Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents Wei, He Wiśniowska, Agata Fan, Jingxuan Harvey, Peter Li, Yuanyuan Wu, Victoria Hansen, Eric C Zhang, Juanye Kaul, Michael G Frey, Abigail M Adam, Gerhard Frenkel, Anatoly I Bawendi, Moungi G Jasanoff, Alan Massachusetts Institute of Technology. Department of Biological Engineering Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemistry >Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in <jats:italic>T</jats:italic><jats:sub>1</jats:sub>-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood–brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials. 2022-02-11T19:39:06Z 2022-02-11T19:39:06Z 2021 2022-02-11T19:36:46Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/140300 Wei, He, Wiśniowska, Agata, Fan, Jingxuan, Harvey, Peter, Li, Yuanyuan et al. 2021. "Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents." Proceedings of the National Academy of Sciences of the United States of America, 118 (42). en 10.1073/PNAS.2102340118 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Wei, He Wiśniowska, Agata Fan, Jingxuan Harvey, Peter Li, Yuanyuan Wu, Victoria Hansen, Eric C Zhang, Juanye Kaul, Michael G Frey, Abigail M Adam, Gerhard Frenkel, Anatoly I Bawendi, Moungi G Jasanoff, Alan Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title | Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title_full | Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title_fullStr | Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title_full_unstemmed | Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title_short | Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents |
| title_sort | single nanometer iron oxide nanoparticles as tissue permeable mri contrast agents |
| url | https://hdl.handle.net/1721.1/140300 |
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