Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta
Abstract Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta...
| Main Authors: | , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer US
2022
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| Online Access: | https://hdl.handle.net/1721.1/140793 |
| _version_ | 1811074950780420096 |
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| author | de Vecchi, Adelaide Faraci, Alessandro Fernandes, Joao F. Marlevi, David Bellsham-Revell, Hannah Hussain, Tarique Laji, Nidhin Ruijsink, Bram Wong, James Razavi, Reza Anderson, David Salih, Caner Pushparajah, Kuberan Nordsletten, David Lamata, Pablo |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science de Vecchi, Adelaide Faraci, Alessandro Fernandes, Joao F. Marlevi, David Bellsham-Revell, Hannah Hussain, Tarique Laji, Nidhin Ruijsink, Bram Wong, James Razavi, Reza Anderson, David Salih, Caner Pushparajah, Kuberan Nordsletten, David Lamata, Pablo |
| author_sort | de Vecchi, Adelaide |
| collection | MIT |
| description | Abstract
Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions.
Graphical abstract |
| first_indexed | 2024-09-23T09:58:01Z |
| format | Article |
| id | mit-1721.1/140793 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:58:01Z |
| publishDate | 2022 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1407932024-03-19T14:12:38Z Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta de Vecchi, Adelaide Faraci, Alessandro Fernandes, Joao F. Marlevi, David Bellsham-Revell, Hannah Hussain, Tarique Laji, Nidhin Ruijsink, Bram Wong, James Razavi, Reza Anderson, David Salih, Caner Pushparajah, Kuberan Nordsletten, David Lamata, Pablo Massachusetts Institute of Technology. Institute for Medical Engineering & Science Abstract Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract 2022-02-28T13:16:40Z 2022-02-28T13:16:40Z 2022-02-23 2022-02-27T04:13:24Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/140793 de Vecchi, Adelaide, Faraci, Alessandro, Fernandes, Joao F., Marlevi, David, Bellsham-Revell, Hannah et al. 2022. "Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta." PUBLISHER_CC en https://doi.org/10.1007/s12265-022-10221-4 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s) application/pdf Springer US Springer US |
| spellingShingle | de Vecchi, Adelaide Faraci, Alessandro Fernandes, Joao F. Marlevi, David Bellsham-Revell, Hannah Hussain, Tarique Laji, Nidhin Ruijsink, Bram Wong, James Razavi, Reza Anderson, David Salih, Caner Pushparajah, Kuberan Nordsletten, David Lamata, Pablo Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title | Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title_full | Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title_fullStr | Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title_full_unstemmed | Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title_short | Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta |
| title_sort | unlocking the non invasive assessment of conduit and reservoir function in the aorta |
| url | https://hdl.handle.net/1721.1/140793 |
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