Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
© 2021 Elsevier Inc. Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts. Several synthetic biological solutions to critical biomedical problems are on the verge of widespread a...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2022
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| Online Access: | https://hdl.handle.net/1721.1/141020 |
| _version_ | 1826213864844296192 |
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| author | Tan, Xiao Letendre, Justin H Collins, James J Wong, Wilson W |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Tan, Xiao Letendre, Justin H Collins, James J Wong, Wilson W |
| author_sort | Tan, Xiao |
| collection | MIT |
| description | © 2021 Elsevier Inc. Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts. Several synthetic biological solutions to critical biomedical problems are on the verge of widespread adoption and demonstrate the burgeoning maturation of the field. Here, we highlight applications of synthetic biology in vaccine development, molecular diagnostics, and cell-based therapeutics, emphasizing technologies approved for clinical use or in active clinical trials. We conclude by drawing attention to recent innovations in synthetic biology that are likely to have a significant impact on future applications in biomedicine. |
| first_indexed | 2024-09-23T15:55:46Z |
| format | Article |
| id | mit-1721.1/141020 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:55:46Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1410202024-03-19T17:35:11Z Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics Tan, Xiao Letendre, Justin H Collins, James J Wong, Wilson W Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Synthetic Biology Center Harvard University--MIT Division of Health Sciences and Technology © 2021 Elsevier Inc. Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts. Several synthetic biological solutions to critical biomedical problems are on the verge of widespread adoption and demonstrate the burgeoning maturation of the field. Here, we highlight applications of synthetic biology in vaccine development, molecular diagnostics, and cell-based therapeutics, emphasizing technologies approved for clinical use or in active clinical trials. We conclude by drawing attention to recent innovations in synthetic biology that are likely to have a significant impact on future applications in biomedicine. 2022-03-04T18:40:20Z 2022-03-04T18:40:20Z 2021 2022-03-04T18:31:26Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141020 Tan, Xiao, Letendre, Justin H, Collins, James J and Wong, Wilson W. 2021. "Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics." Cell, 184 (4). en 10.1016/J.CELL.2021.01.017 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Tan, Xiao Letendre, Justin H Collins, James J Wong, Wilson W Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title | Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title_full | Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title_fullStr | Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title_full_unstemmed | Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title_short | Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics |
| title_sort | synthetic biology in the clinic engineering vaccines diagnostics and therapeutics |
| url | https://hdl.handle.net/1721.1/141020 |
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