Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines
Dengue is the most common arboviral disease caused by one of four distinct but closely related dengue viruses (DENV) and places significant economic and public health burdens in the endemic areas. A dengue vaccine will be important in advancing disease control. However, the effort has been challenge...
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| Format: | Article |
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Frontiers Media SA
2022
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| Online Access: | https://hdl.handle.net/1721.1/141032 |
| _version_ | 1826210259404849152 |
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| author | Hou, Jue Ye, Weijian Chen, Jianzhu |
| author2 | Singapore-MIT Alliance in Research and Technology (SMART) |
| author_facet | Singapore-MIT Alliance in Research and Technology (SMART) Hou, Jue Ye, Weijian Chen, Jianzhu |
| author_sort | Hou, Jue |
| collection | MIT |
| description | Dengue is the most common arboviral disease caused by one of four distinct but closely related dengue viruses (DENV) and places significant economic and public health burdens in the endemic areas. A dengue vaccine will be important in advancing disease control. However, the effort has been challenged by the requirement to induce effective protection against all four DENV serotypes and the potential adverse effect due to the phenomenon that partial immunity to DENV may worsen the symptoms upon subsequent heterotypic infection. Currently, the most advanced dengue vaccines are all tetravalent and based on recombinant live attenuated viruses. CYD-TDV, developed by Sanofi Pasteur, has been approved but is limited for use in individuals with prior dengue infection. Two other tetravalent live attenuated vaccine candidates: TAK-003 by Takeda and TV003 by National Institute of Allergy and Infectious Diseases, have completed phase 3 and phase 2 clinical trials, respectively. This review focuses on the designs and evaluation of TAK-003 and TV003 vaccine candidates in humans in comparison to the licensed CYD-TDV vaccine. We highlight specific lessons from existing studies and challenges that must be overcome in order to develop a dengue vaccine that confers effective and balanced protection against all four DENV serotypes but with minimal adverse effects. |
| first_indexed | 2024-09-23T14:46:58Z |
| format | Article |
| id | mit-1721.1/141032 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:46:58Z |
| publishDate | 2022 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1410322023-04-20T19:40:39Z Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines Hou, Jue Ye, Weijian Chen, Jianzhu Singapore-MIT Alliance in Research and Technology (SMART) Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Dengue is the most common arboviral disease caused by one of four distinct but closely related dengue viruses (DENV) and places significant economic and public health burdens in the endemic areas. A dengue vaccine will be important in advancing disease control. However, the effort has been challenged by the requirement to induce effective protection against all four DENV serotypes and the potential adverse effect due to the phenomenon that partial immunity to DENV may worsen the symptoms upon subsequent heterotypic infection. Currently, the most advanced dengue vaccines are all tetravalent and based on recombinant live attenuated viruses. CYD-TDV, developed by Sanofi Pasteur, has been approved but is limited for use in individuals with prior dengue infection. Two other tetravalent live attenuated vaccine candidates: TAK-003 by Takeda and TV003 by National Institute of Allergy and Infectious Diseases, have completed phase 3 and phase 2 clinical trials, respectively. This review focuses on the designs and evaluation of TAK-003 and TV003 vaccine candidates in humans in comparison to the licensed CYD-TDV vaccine. We highlight specific lessons from existing studies and challenges that must be overcome in order to develop a dengue vaccine that confers effective and balanced protection against all four DENV serotypes but with minimal adverse effects. 2022-03-07T14:50:28Z 2022-03-07T14:50:28Z 2022-02-24 Article http://purl.org/eprint/type/JournalArticle 1664-3224 https://hdl.handle.net/1721.1/141032 Hou, Jue, Ye, Weijian and Chen, Jianzhu. 2022. "Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines." Frontiers in Immunology, 13. 10.3389/fimmu.2022.840104 Frontiers in Immunology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Hou, Jue Ye, Weijian Chen, Jianzhu Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title | Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title_full | Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title_fullStr | Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title_full_unstemmed | Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title_short | Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines |
| title_sort | current development and challenges of tetravalent live attenuated dengue vaccines |
| url | https://hdl.handle.net/1721.1/141032 |
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