Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy. In lipid...

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Bibliographic Details
Main Authors: Mandala, Venkata S, McKay, Matthew J, Shcherbakov, Alexander A, Dregni, Aurelio J, Kolocouris, Antonios, Hong, Mei
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/141070

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